Actively Recruiting
Comparing High-flow Nasal Cannula Oxygen and Noninvasive Ventilation to Standard Oxygenation in Non-selected ICU Patients Admitted for Hypoxemic ARF
Led by University Hospital, Montpellier · Updated on 2025-05-07
2100
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether one of the two oxygenation or ventilation strategies (NIV and/or HFNO) is superior to standard oxygen to reduce 28-day mortality rate in hypoxemic acute respiratory failure (ARF) patients.
CONDITIONS
Official Title
Comparing High-flow Nasal Cannula Oxygen and Noninvasive Ventilation to Standard Oxygenation in Non-selected ICU Patients Admitted for Hypoxemic ARF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (age 38 years)
- Diagnosis of hypoxemic acute respiratory failure persisting more than 30 minutes, defined by low oxygen levels (PaO2 <60 mm Hg on room air or <80 mmHg on 15 L/min oxygen, or SpO2 390% on room air) or PaO2/FiO2 ratio <300 mmHg plus rapid breathing or signs of intense breathing effort
You will not qualify if you...
- Contraindications to noninvasive ventilation and/or high-flow nasal oxygen
- Sleep apnea requiring home ventilator
- Immediate need for tracheal intubation
- Requirement for emergency surgery needing intubation
- High carbon dioxide levels needing NIV (PaCO2 350 mmHg or clinical signs)
- Isolated cardiogenic pulmonary edema (NIV indicated)
- Anatomical reasons preventing use of NIV or HFNO
- Do-not-intubate orders or limitation of life-support therapies
- Pregnancy during study or breastfeeding
- Adults protected by law or under guardianship/curatorship
- Not covered by public health insurance
- Lack of written informed consent from patient or proxy before inclusion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Montpellier University Hospital - Saint Eloi Hospital
Montpellier, France, 34295
Actively Recruiting
Research Team
S
Samir Jaber, MD, PhD
CONTACT
A
Audrey DE JONG, MD,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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