Comparing High-Protein and Standard Protein Nutritional Support Using Whey Protein Supplements in Critically Ill Adults at Risk for Refeeding Syndrome

What this Trial Is About

This clinical trial is focused on critically ill patients who are at risk for refeeding syndrome RS and are receiving supportive nutrition in an ICU setting. Researchers aim to find the best protein administration method to improve nutritional and clinical outcomes, reduce complications, and lower mortality. The study tests the hypothesis that a higher protein intake may decrease the occurrence of refeeding syndrome and improve overall patient outcomes, including shorter ICU and hospital stays. Participants are randomly assigned to either a high-protein group or a standard-protein group. Both groups receive nutritional support starting with low calorie intake that gradually increases. The high-protein group targets 2 grams of protein per kilogram of body weight per day, while the standard-protein group targets 1.3 grams per kilogram per day. Protein is gradually introduced, with whey protein powder added if needed, and the intervention lasts for 14 days with a minimum of 5 days. All patients receive daily thiamine and multivitamin-mineral supplements during the study. During the trial, patients are closely monitored with daily laboratory tests for key blood levels and organ function using scoring systems like SOFA. Researchers track the number of patients who develop refeeding syndrome within the first week, as well as secondary outcomes like infections, organ failure, length of ICU and hospital stays, and mortality up to 45 days after admission. The study involves regular assessments and careful monitoring to understand the effects of protein intake on these critically ill patients.

Comparing High-protein Vs. Standard Protein Nutritional Support in Critically Ill Patients At Risk for Refeeding Syndrome