Early Phase I Study Comparing F-18 NaF PETCT to Standard F-18 FDG PETCT Imaging for Detecting Radiation Effects on Neck Blood Vessels in Head and Neck Cancer Patients

What this Trial Is About

Researchers are evaluating whether an investigational PETCT scan using sodium fluoride F-18 F-18 NaF is as effective or more effective than the standard PETCT scan using fludeoxyglucose F-18 F-18 FDG for assessing how radiation therapy affects blood vessels in the neck of patients with head and neck cancers. The study focuses on patients receiving radiation targeting tumors and nearby glands, as radiation can impact the blood vessels supplying the brain. Participants are assigned to one of two groups. One group receives intensity-modulated radiation therapy IMRT and the other receives intensity-modulated proton therapy IMPT, both considered standard treatments. Each participant undergoes PETCT scans using F-18 NaF within 28 days before starting radiation and again 12 weeks after completing radiation. These scans are compared to standard F-18 FDG PETCT scans done at the same times. During the study, patients receive intravenous F-18 NaF and undergo PETCT imaging before and after their radiation treatment. Researchers assess radiation-induced vascular complications and inflammation up to six months after therapy. They also measure brain glucose uptake to explore effects on brain function. After completing imaging and treatment, patients are followed up within one to five business days to monitor outcomes and safety.

Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer