Actively Recruiting
Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
Led by Wake Forest University Health Sciences · Updated on 2025-10-28
153
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.
CONDITIONS
Official Title
Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years or older
- Able to provide informed consent
- Primary diagnosis of atrial fibrillation or atrial flutter with rapid ventricular response (heart rate ≥ 120 bpm)
- Currently treated with diltiazem as a rate control agent
- Able to speak and understand English
You will not qualify if you...
- Hemodynamically unstable patients (systolic blood pressure < 90, mean arterial pressure < 65)
- Impaired consciousness
- End stage renal disease requiring hemodialysis or peritoneal dialysis
- Acute heart failure exacerbation diagnosed clinically or with imaging
- AFF RVR suspected to be a compensatory response to another diagnosis
- Heart rhythms other than atrial fibrillation, such as sick sinus syndrome or wide-complex ventricular response
- Acute myocardial infarction
- Pregnancy (positive urine human chorionic gonadotropin test)
- Contraindications to magnesium sulfate (including myasthenia gravis)
- Allergy or sensitivity to any study drugs
- Previously enrolled in this trial during a different encounter
- Withdrawal from the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Advocate Christ Medical Center Emergency Department (ACMC ED)
Oak Lawn, Illinois, United States, 60453
Actively Recruiting
Research Team
M
Marc McDowell, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here