Actively Recruiting

Phase 2
Age: 18Years +
MALE
NCT06409910

Comparing Moderately Ultra Hypofractionated Radiation Treatments for Prostate Cancer

Led by University Health Network, Toronto · Updated on 2026-03-23

204

Participants Needed

2

Research Sites

309 weeks

Total Duration

On this page

Sponsors

U

University Health Network, Toronto

Lead Sponsor

T

TOLMAR PHARMACEUTIQUES CANADA, INC.

Collaborating Sponsor

AI-Summary

What this Trial Is About

This is a multi-institution, randomized, non-inferiority Phase II trial comparing external beam radiotherapy delivered as 54 Gy in 20 fractions to prostate bed +/- 44 Gy in 20 fractions to pelvic lymph nodes delivered daily with external beam radiotherapy delivered as 30 Gy in 5 fractions to prostate bed +/- 25 Gy in 5 fractions to pelvic lymph nodes delivered on alternate days.

CONDITIONS

Official Title

Comparing Moderately Ultra Hypofractionated Radiation Treatments for Prostate Cancer

Who Can Participate

Age: 18Years +
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Able to provide informed consent
  • Histologic diagnosis of prostate adenocarcinoma
  • ECOG performance status 0-1
  • Previous radical prostatectomy more than 6 months before radiotherapy start
  • Planned to receive post-operative radiation
Not Eligible

You will not qualify if you...

  • Prior pelvic radiotherapy
  • Contraindications to radiotherapy
  • Confirmed metastases if imaging has been done
  • Visible disease in prostate bed or pelvic lymph nodes on imaging

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

London Health Sciences Centre

London, Ontario, Canada, N6A 5W9

Actively Recruiting

2

University Health Network - Princess Margaret Cancer Centre

Toronto, Ontario, Canada, M5G 2C1

Actively Recruiting

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Research Team

A

Andrew McPartlin, MBChB

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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