Study on Respiratory Tract Infection Risk in Postmenopausal Women Aged 40-60 Taking or Not Taking Hormone Replacement Therapy

What this Trial Is About

Respiratory tract infections RTIs are a significant health concern worldwide, causing substantial illness and disability. This study focuses on postmenopausal women aged 40 to 60 years to explore how hormone replacement therapy HRT may influence the frequency and severity of RTIs. The research aims to better understand risk factors for RTIs during menopause and evaluate how wearable technology can predict infection onset before symptoms appear. The study observes two groups of women those taking HRT and those not taking HRT. Over six months, participants will wear a smartwatch to continuously monitor physiological data such as heart rate and sleep patterns. They will also complete questionnaires about lifestyle, medical history, and environmental exposure. RTI episodes will be tracked through self-reporting and confirmed by lab tests. Data analysis will use statistical and machine learning methods to identify predictors of RTI and develop an early-warning model. Participants will be followed for six months from enrollment, during which researchers will record the number and severity of RTI episodes. Wearable devices and questionnaires will provide ongoing data, while laboratory confirmation will validate infections. The study will assess daily individual risk of RTI onset and correlations between participant characteristics and infection outcomes. Findings aim to support personalized prevention strategies and improve respiratory health management in postmenopausal women.

Comparing and Predicting the Risk of Respiratory Tract Infection (RTI) Among Post-menopausal Women on or Without Hormone Replacement Therapy (HRT): an Observational Cohort Study