Actively Recruiting
Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.
Led by Integrative Skin Science and Research · Updated on 2026-04-22
30
Participants Needed
1
Research Sites
58 weeks
Total Duration
On this page
Sponsors
I
Integrative Skin Science and Research
Lead Sponsor
A
Almirall, S.A.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to help better understand how the gut and skin bacteria of the body change when people with acne are treated with Sarecycline or Doxycycline. The bacteria in the gut and on the skin will be studied to see how each treatment may affect them and whether they change the profile of the bacteria that is present.
CONDITIONS
Official Title
Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acne vulgaris with at least 10 inflammatory lesions (papules, pustules, nodules) and up to 100 noninflammatory lesions (open and closed comedones)
- No more than 2 nodules on the face
- Participants aged 9 years and older
You will not qualify if you...
- Any dermatological condition on the face or facial hair that could affect clinical evaluations
- Use of topical acne medications, benzoyl peroxide, anti-inflammatories, or corticosteroids on the face within 2 weeks before randomization
- Use of systemic antibiotics, systemic acne treatments, oral probiotic supplements, or systemic corticosteroids within 4 weeks before randomization
- Use of systemic retinoids within 12 weeks before randomization
- Change in hormonal contraception or therapies within 3 months prior to joining the study
- Pregnancy or breastfeeding
- Use of oral contraceptive pills or progesterone or estrogen therapies unless stable dose for at least 2 months
- Use of finasteride or dutasteride
- Current tobacco smoker or tobacco smoking history greater than 5 pack-years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Integrative Research Institute
Sacramento, California, United States, 95819
Actively Recruiting
Research Team
N
Nasima Afzal Chief Operating Officer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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