Actively Recruiting
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
Led by Stanford University · Updated on 2025-07-16
274
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS. Patients will be randomized to treatment with spine SRS using either 22 Gy in 1 fraction or 28 Gy in 2 fractions.
CONDITIONS
Official Title
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically, cytologically, or radiographically confirmed diagnosis of metastatic cancer
- Age 18 years or older
- Presence of cervical, thoracic, or lumbar spine metastasis needing treatment
- 1 to 3 separate spinal sites requiring treatment
- Each spinal site covers 1-2 contiguous vertebral levels
- ECOG performance status 0 to 2
- Negative serum or urine pregnancy test within 14 days before enrollment for people of childbearing potential or not postmenopausal
- People of childbearing potential and sexually active males must agree to use effective birth control
- Ability and willingness to provide informed consent (personally or by legal representative)
You will not qualify if you...
- Prior or planned radiation overlapping or within the study treatment site outside the study
- Inability to have either an MRI or CT scan (pacemaker patients allowed CT)
- Pediatric patients under 18 years old
- Pregnant or nursing women
- Diagnosis of myeloma or lymphoma
- Muscle strength of 1-3 out of 5, bladder or bowel incontinence, or bladder retention related to the spinal site to be treated
- Prior surgery to the spinal site intended for study SRS treatment
- Spinal Instability Neoplastic Score (SINS) between 13 and 18
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University School of Medicine
Palo Alto, California, United States, 94305
Actively Recruiting
Research Team
K
Kelly Huang
CONTACT
A
Alyssa Yauger
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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