A Study Comparing Superpulse Thulium Fiber Laser and HolmiumYAG Laser for Treating Kidney and Upper Ureteral Stones During Ureteroscopy in Adults

What this Trial Is About

This research aims to compare the clinical effectiveness and safety of two types of lasers, superpulse thulium fiber laser sTFL and holmiumYAG laser HoYAG, used during flexible ureteroscopy FURS lithotripsy for adults aged 18 to 70 years with kidney or upper ureteral stones measuring 6-20mm. The study focuses on whether sTFL results in a higher stone-free rate three months after surgery, as well as differences in operation time, complication rates, and the surgeons visual experience. Participants will be randomly assigned to receive FURS lithotripsy using either the sTFL or HoYAG laser under general anesthesia. Experienced urologists will perform all procedures, adjusting laser settings based on the stone characteristics to optimize treatment. The study includes several visits a baseline screening, intraoperative procedure, postoperative monitoring within 24 hours, and follow-up visits at 3 and 6 months to assess stone clearance and recurrence using CT scans. During the study, participants will undergo CT scans at 3 and 6 months post-operation to check for remaining stones and recurrence. Researchers will monitor vital signs, document any complications using the Clavien-Dindo classification, and evaluate the surgeons visual experience concerning clarity, efficiency, stone movement, and tissue injury. Adverse events will be recorded throughout the study, which is expected to last until October 2028.

Comparing Super Pulse Fiber Thulium Laser and Holmium Laser for Ureteral Stone Fragmentation During Ureteroscopy