Actively Recruiting
Led by Medipol University · Updated on 2025-12-08
90
Participants Needed
1
Research Sites
4 weeks
Total Duration
Researchers are evaluating the effects of two regional anesthesia techniques, the Thoracolumbar Interfascial Plane (TLIP) block and the Quadro Iliac Plane Block, on postoperative opioid use after lumbar microsurgery. This study aims to compare these methods to standard perioperative analgesia in patients undergoing lumbar microdiscectomy, focusing on pain management and opioid consumption. The study also examines opioid-related side effects and pain scores to better understand the impact of these blocks on recovery. Participants are randomly assigned to one of three groups: standard perioperative analgesia without any additional block, TLIP block plus standard analgesia, or Quadro Iliac Plane Block plus standard analgesia. Both the TLIP and Quadro Iliac Plane Blocks involve ultrasound-guided injections of 20 mL of 0.25% bupivacaine administered after surgery but before awakening. The study compares these approaches to determine differences in opioid consumption and side effects. During the first 24 hours after surgery, researchers will monitor tramadol use, pain scores using the Numeric Rating Scale, and opioid-related side effects such as nausea, vomiting, and respiratory depression. Patients will be assessed for their pain levels and any side effects to evaluate the effectiveness and safety of each analgesic approach. The study runs from March 2025 to April 2026 and includes adults aged 18 to 80 undergoing lumbar microdiscectomy.
CONDITIONS
Comparing Thoracolumbar Interfascial and Quadro Iliac Plane Blocks on Postoperative Opioid Use Following Lumbar Microsurgery
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo lumbar microdiscectomy surgery and receive either standard perioperative analgesia alone or combined with a regional block (Thoracolumbar Interfascial Plane Block or Quadro Iliac Plane Block) administered under ultrasound guidance before awakening.
1 visit (in-person) on surgery day
Duration - First 24 hours after the operation
Participants are monitored for opioid consumption, pain levels using the Numeric Rating Scale, and opioid-related side effects such as nausea, vomiting, and respiratory depression following surgery.
1 to 2 visits within 24 hours after surgery
Total: 1 location
1
Medipol University
Istanbul, Turkey (Türkiye)
Actively Recruiting
B
Burak Ömür
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Şenay Canikli Adıgüzel, Dilan Akyurt, Hatice Bahadır Altun...
https://pubmed.ncbi.nlm.nih.gov/38068268Zhenxin Hu, Jun Han, Binbin Jiao...
https://pubmed.ncbi.nlm.nih.gov/34704718Emine Yıldırım Uslu
https://pubmed.ncbi.nlm.nih.gov/38915966