Study Comparing Three Rescue Bowel Preparations for Adults Needing Repeat Colonoscopy After Poor Bowel Cleansing

What this Trial Is About

Researchers are evaluating which rescue bowel preparation works best for adults who need a repeat colonoscopy after an earlier bowel preparation did not clean the bowel well enough. The study aims to find out which preparation helps more participants achieve adequate bowel cleansing, which one cleans different colon parts better, and which is better tolerated by participants. This trial compares three rescue bowel preparation regimens to answer these questions. Participants will be randomly assigned to one of three groups before their repeat colonoscopy one group will take 4 liters of polyethylene glycol PEG plus 12 mg of bisacodyl another group will take 1 liter of PEG plus ascorbic acid and 10 mg of bisacodyl and the third group will take 2 liters of PEG plus extra PEG over the three days before the procedure. Each preparation is given as a rescue method after a previous inadequate bowel cleansing. During the study, participants will undergo the repeat colonoscopy where researchers will assess bowel cleansing quality using the Boston Bowel Preparation Scale in different colon sections. Participants will also rate their satisfaction with their bowel preparation. Researchers will monitor polyp detection and bowel preparation adequacy on the day of colonoscopy. The study is sponsored by Ospedale San Pio and runs until June 2026.

Comparing Three Rescue Bowel Preparation Regimens for Colonoscopy After Failed Cleansing