Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Pain Relief After Root Canal Treatment A Randomized Controlled Trial in Adults Aged 18 to 45

What this Trial Is About

Researchers are evaluating the pain reduction effects of Trypsin-Chymotrypsin compared to Naproxen Sodium in patients with symptomatic irreversible pulpitis after root canal treatment. This study addresses the issue of significant post-treatment pain that often causes patients to avoid dental care, aiming to find an effective pain management option. Conducted as a triple-blinded, randomized controlled trial, it seeks to determine if there is any difference in pain relief between these two medications. The trial includes 100 patients randomly assigned to two groups one receives Trypsin-Chymotrypsin tablets three times a day before meals for 24 hours, while the other group takes Naproxen Sodium 550mg twice a day after meals for 24 hours. Both treatments follow standard root canal therapy. The medications are given in sealed envelopes to maintain blinding and reduce bias. Participants will report their pain levels using a numerical rating scale at 1, 6, 12, and 24 hours after treatment. Researchers will monitor and compare the change in pain scores between the two groups over this period. The study is designed to minimize bias with computer-generated randomization and quadruple masking, ensuring reliable results about the effectiveness of these pain management options after endodontic treatment.

Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain