Comparing Macro- and Microvascular Responses to Acute Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults a Parallel Group Crossover Randomized Trial

What this Trial Is About

Researchers are studying how aging affects muscle strength and blood vessel function during resistance exercise, comparing responses between young adults 18-30 years and older adults over 60 years. The study focuses on how aging reduces nitric oxide availability and microvascular function, which impacts muscle performance and overall physical ability. It aims to understand the effects of different resistance training methods on vascular health in these age groups. Participants will be randomly assigned to one of two exercise groups low intensity resistance training with blood flow restriction LIRT-BFR or high intensity resistance training without blood flow restriction HIRT. The LIRT-BFR group performs 4 sets of 20 repetitions at 30 of their one-repetition maximum 1-RM with cuffs restricting blood flow on the upper thighs, while the HIRT group performs 3 sets of 10 repetitions at 75 1-RM without blood flow restriction. Each participant attends three sessions, including a familiarization visit and two exercise sessions spaced at least one week apart. During each session, participants rest supine for 15 minutes before measurements of blood pressure, heart rate, and microvascular function are taken at rest and after exercise. After completing the assigned exercise, these measurements are repeated at 5 and 30 minutes into recovery. The study tracks changes in macrovascular and microvascular function, arterial stiffness, and blood pressure to understand vascular responses to these exercise types. Researchers ensure participant safety with trained staff and monitor adherence to pre-visit instructions such as avoiding caffeine, alcohol, and vigorous exercise 24 hours before sessions.

Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults