Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID06596304

Comparing Macro- and Microvascular Responses to Acute Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults: a Parallel Group Crossover Randomized Trial

Led by Egas Moniz - Cooperativa de Ensino Superior, CRL · Updated on 2024-10-23

52

Participants Needed

2

Research Sites

8 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying how aging affects muscle strength and blood vessel function during resistance exercise, comparing responses between young adults (18-30 years) and older adults (over 60 years). The study focuses on how aging reduces nitric oxide availability and microvascular function, which impacts muscle performance and overall physical ability. It aims to understand the effects of different resistance training methods on vascular health in these age groups. Participants will be randomly assigned to one of two exercise groups: low intensity resistance training with blood flow restriction (LIRT-BFR) or high intensity resistance training without blood flow restriction (HIRT). The LIRT-BFR group performs 4 sets of 20 repetitions at 30% of their one-repetition maximum (1-RM) with cuffs restricting blood flow on the upper thighs, while the HIRT group performs 3 sets of 10 repetitions at 75% 1-RM without blood flow restriction. Each participant attends three sessions, including a familiarization visit and two exercise sessions spaced at least one week apart. During each session, participants rest supine for 15 minutes before measurements of blood pressure, heart rate, and microvascular function are taken at rest and after exercise. After completing the assigned exercise, these measurements are repeated at 5 and 30 minutes into recovery. The study tracks changes in macrovascular and microvascular function, arterial stiffness, and blood pressure to understand vascular responses to these exercise types. Researchers ensure participant safety with trained staff and monitor adherence to pre-visit instructions such as avoiding caffeine, alcohol, and vigorous exercise 24 hours before sessions.

CONDITIONS

Brief Title

Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged between 18 and 30 years or over 60 years
Not Eligible

You will not qualify if you...

  • Past or current history of coronary heart disease, stroke, cancer, or major cardiovascular events
  • Surgery within the last two months
  • Body mass index (BMI) greater than 30 kg/m²
  • Declared sleep apnea
  • Active kidney or liver disease
  • Active tobacco smokers
  • Sensory impairments
  • Neurological or orthopedic problems affecting exercise capacity
  • Physically active for more than six months with weekly activity over 1,000 MET/minutes per week
  • Musculoskeletal conditions limiting exercise ability

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Baseline Assessments and Familiarization

Duration - 1 day

Participants visit the laboratory to have their body weight and height measured, undergo vascular function evaluations at rest, and become familiar with the exercise protocol including determination of their one-repetition maximum (1RM) for bilateral leg press and knee extension.

1 visit (in-person)

Experimental Exercise Sessions

Duration - 3 visits spaced at least 1 week apart

Participants perform two different resistance training conditions in randomized order: low intensity-resistance training with blood flow restriction (LIRT-BFR) and high intensity resistance training (HIRT). Each session includes pre-exercise rest, exercise for approximately 30 minutes, and post-exercise recovery with repeated vascular and cardiovascular assessments.

2 exercise visits plus 1 baseline visit

Trial Site Locations

Total: 2 locations

1

Egas Moniz School of Health and Science

Almada, Monte Da Caparica, Portugal, 2829-511

Not Yet Recruiting

2

Egas Moniz School of Health and Science

Almada, Setúbal District, Portugal, 2829-511

Actively Recruiting

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Research Team

X

Xavier Melo, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

3

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Published Research Related To This Trial

The effect of four weeks blood flow restricted resistance training on macro- and micro-vascular function in healthy, young men.

Masahiro Horiuchi, Lee Stoner, Jillian Poles

https://pubmed.ncbi.nlm.nih.gov/37245196

Effects of exercise training with blood flow restriction on vascular function in adults: a systematic review and meta-analysis.

Elisio A Pereira-Neto, Hayley Lewthwaite, Terry Boyle...

https://pubmed.ncbi.nlm.nih.gov/34277146

Effects of Low-Load Blood Flow Restriction Training on Hemodynamic Responses and Vascular Function in Older Adults: A Meta-Analysis.

Tianqi Zhang, Guixian Tian, Xing Wang

https://pubmed.ncbi.nlm.nih.gov/35682336

Exploring the Association between Vascular Dysfunction and Skeletal Muscle Mass, Strength and Function in Healthy Adults: A Systematic Review.

Svyatoslav Dvoretskiy, Jacqueline C Lieblein-Boff, Satya Jonnalagadda...

https://pubmed.ncbi.nlm.nih.gov/32156061