A Randomized Study Comparing 3D and Standard 2D Colonoscopy for Surveillance in Adults 40 and Older

What this Trial Is About

Researchers are evaluating the effectiveness of 3D colonoscopy compared to standard 2D colonoscopy during surveillance colonoscopy in patients aged 40 and older. The study focuses on improving adenoma detection rate ADR, which is crucial for preventing colorectal cancer and reducing mortality. Detecting non-polypoid lesions, which are often missed by traditional methods, is a key concern as these lesions contribute to post-colonoscopy colorectal cancer. Participants will be randomly assigned to receive either 3D colonoscopy using a specialized 3D imaging device or standard 2D colonoscopy. This multicenter, prospective, randomized controlled trial compares how well each method detects adenomas and polyps during surveillance colonoscopy performed at least one year after prior colonoscopy and polypectomy. During the study, participants will undergo colonoscopy with monitoring of various detection rates, including overall ADR, flat-ADR, proximal and distal ADR, and polyp detection rates. Researchers will assess adenoma numbers per colonoscopy and evaluate safety and quality of bowel preparation. The primary outcome is the adenoma detection rate within 30 minutes. The study includes double masking to reduce bias and will follow participants until February 2027.

Comparison of Adenoma Detection Rate in 3D vs. 2D Surveillance Colonoscopy