Randomized Trial Comparing Cingal (Sodium Hyaluronate/Triamcinolone) Versus Cortisone (Triamcinolone) Injections for Shoulder Osteoarthritis

What this Trial Is About

Researchers are evaluating the pain relief effects of two types of shoulder joint injections for patients with moderate to severe osteoarthritis. The trial compares an injection called Cingal, which combines sodium hyaluronate and triamcinolone, against a standard cortisone injection containing triamcinolone. The study aims to determine if Cingal provides better pain control and functional improvement in the shoulder than cortisone alone. The study involves 84 patients randomly assigned to receive a single injection of either Cingal (4 mL, containing 88 mg of hyaluronic acid and 18 mg of triamcinolone hexacetonide) or cortisone (40 mg of triamcinolone with 4 mL of bupivacaine 0.25%). Before treatment, all participants undergo shoulder X-rays and MRI scans. The injection is performed under fluoroscopy by a radiologist. After treatment, patients complete electronic questionnaires and maintain a medication diary at 1, 3, and 6 months. Participants will be monitored through pain assessments using the visual analogue scale (VAS) at 1, 3, and 6 months after injection, which is the primary outcome at 3 months. Functional ability is evaluated with QuickDash questionnaires at the same time points. Medical history, demographic data, and baseline questionnaires are collected before injection to measure changes over time. The study follows patients for six months to assess both pain relief and shoulder function after treatment.

Comparison of the Analgesic Effect of 2 Shoulder Infiltrations