Actively Recruiting
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Led by Yale University · Updated on 2025-08-27
300
Participants Needed
13
Research Sites
248 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.
CONDITIONS
Official Title
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Enrollment in the CAPTIVA trial with nondisabling symptomatic ischemic stroke within 30 days due to 70-99% narrowing of intracranial carotid, middle cerebral, basilar, or vertebral arteries
- Ability to have a baseline MRI scan within 14 days of CAPTIVA trial enrollment
You will not qualify if you...
- Unable or unwilling to have MRI, including having a pacemaker or other MRI contraindications per American College of Radiology guidelines
- Allergy to gadolinium contrast or acute or chronic kidney disease with estimated glomerular filtration rate (eGFR) less than 30 ml/min/1.73m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
University of Alabama Hospital
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Yale New Haven Hospital
New Haven, Connecticut, United States, 06510
Not Yet Recruiting
3
MedStar Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010
Not Yet Recruiting
4
Baptist Medical Center Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
5
Jackson Memorial Hospital, Miami
Miami, Florida, United States, 33136
Actively Recruiting
6
SIH Memorial Hospital of Carbondale
Carbondale, Illinois, United States, 62901
Not Yet Recruiting
7
University of Illinois Hospital
Chicago, Illinois, United States, 60612
Actively Recruiting
8
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
9
Barnes Jewish Hospital
St Louis, Missouri, United States, 63108
Actively Recruiting
10
Buffalo General Medical Center
Buffalo, New York, United States, 14203
Actively Recruiting
11
North Shore University Hospita
Manhasset, New York, United States, 11030
Actively Recruiting
12
Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Not Yet Recruiting
13
UH Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
K
Ka-Ho Wong
CONTACT
A
Amy Sulken
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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