Actively Recruiting

Early Phase 1
Age: 18Years - 79Years
All Genders
Healthy Volunteers
NCT06933056

Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs

Led by University of Michigan · Updated on 2025-09-15

20

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

Sponsors

U

University of Michigan

Lead Sponsor

L

Lexicon Pharmaceuticals

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.

CONDITIONS

Official Title

Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs

Who Can Participate

Age: 18Years - 79Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 79 years
  • Weight greater than 60 kilograms
  • All genders are eligible
Not Eligible

You will not qualify if you...

  • Students under the direct supervision of Dr. Michael Holinstat
  • Diagnosed with Type I diabetes or ketoacidosis
  • History of alcohol abuse, pancreatitis, pancreatic surgery, or on a ketogenic diet
  • Women who are pregnant, planning pregnancy during the 14-week study, or breastfeeding
  • Hypersensitivity to aspirin, clopidogrel, apixaban, or sotagliflozin
  • Active bleeding or history of balanitis, balanoposthitis, genital mycotic infections
  • Planned elective surgical or dental procedures within 1 month before or after the study
  • Use of NSAIDs or aspirin within 7 days prior to study or anticoagulants within 10 days prior
  • Currently taking SSRIs, SNRIs, lithium, or omeprazole/esomeprazole
  • Creatinine level greater than or equal to 1.5 mg/dl

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

University of Michigan

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

Loading map...

Research Team

A

Amanda Prieur

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

PREVENTION

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here