Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID07030764

Comparison of Arthrogenic Muscle Inhibition (AMI) After ACL Reconstruction in Patients With Conventional Rehabilitation or Combined With DOCT'UP Digital Therapy

Led by GCS Ramsay Santé pour l'Enseignement et la Recherche · Updated on 2025-09-29

448

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating the recovery process after anterior cruciate ligament (ACL) rupture, focusing on a condition called arthrogenic muscle inhibition (AMI). AMI reduces the ability of the quadriceps muscle to activate properly despite intact nerve and muscle structures, limiting recovery and rehabilitation after ACL injury. The study aims to assess whether adding a digital therapy tool to conventional rehabilitation can better address these neuromuscular deficits and improve patient outcomes. The trial compares two rehabilitation approaches following ACL reconstruction: conventional physiotherapy alone, which includes 40 supervised sessions, and augmented rehabilitation combining these physiotherapy sessions with the DOCT'UP digital therapy. DOCT'UP is a mobile application that supports patients with home-based exercises targeting AMI and general recovery. The digital therapy aims to enhance patient engagement and adherence alongside standard physical therapy. Participants will undergo scheduled physiotherapy sessions and use the mobile app as part of their rehabilitation. Researchers will monitor outcomes such as the rate of AMI at three weeks and adherence to physiotherapy over six months. Patients will be assessed for muscle function recovery, pain, and complications like Cyclops syndrome. The total participation includes follow-up assessments to evaluate the impact of the combined digital and conventional rehabilitation on recovery quality.

CONDITIONS

Brief Title

Comparison of Arthrogenic Muscle Inhibition (AMI) After ACL Reconstruction in Patients With Conventional Rehabilitation or Conventional Rehabilitation Combined With Digital Therapy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient, male or female, aged 2018 years or older
  • Scheduled for primary ACL reconstruction surgery
  • Has a smartphone and is able to use mobile applications
  • Affiliated with or benefits from a social security scheme
  • French-speaking and has signed an informed consent form
Not Eligible

You will not qualify if you...

  • Presence of residual arthrogenic muscle inhibition (AMI)
  • Previous surgery on the same or opposite knee
  • Multi-ligament injury
  • Contraindications to physical exercise such as severe cardiovascular disease or uncontrolled metabolic disease
  • Cognitive problems
  • No internet access
  • Participation in another study
  • Pregnant or breastfeeding women
  • Under legal protection such as guardianship, curatorship, or deprived of liberty by judicial or administrative decision

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery

Duration - 1 day

Participants undergo ACL reconstruction surgery as part of their treatment.

1 visit (in-person)

Outpatient Treatment

Duration - Up to 6 months

Participants receive conventional physiotherapy sessions, with some also using DOCT'UP® digital therapy at home as part of their rehabilitation.

40 physiotherapy sessions plus digital therapy at home as applicable

Trial Site Locations

Total: 1 location

1

Hôpital Privé Jean Mermoz

Lyon, France, France, 69008

Actively Recruiting

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Research Team

B

Benjamin FREYCHET, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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