Comparison of Norepinephrine and Phenylephrine Boluses for Preventing Low Blood Pressure During Spinal Anesthesia in Women Undergoing Emergency Cesarean Section A Double-Blind Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating whether norepinephrine is more effective than phenylephrine in preventing low blood pressure caused by spinal anesthesia in women undergoing emergency cesarean sections. This study focuses on comparing these two drugs to see which one better reduces the incidence of spinal anesthesia induced hypotension, a common complication affecting both mother and baby during cesarean delivery. The research is conducted under a double-blind, randomized controlled trial design. Participants receive either a prophylactic bolus of norepinephrine or phenylephrine immediately after spinal anesthesia is given. In case of hypotension, rescue boluses of lower doses of the same drugs are administered. The study groups include Group N receiving norepinephrine and Group P receiving phenylephrine, with drug doses carefully monitored throughout the procedure. During the study, maternal heart rate, blood pressure, and other hemodynamic parameters are recorded every 3 minutes until the baby is delivered. Additionally, the newborn's APGAR scores are assessed to monitor immediate health. Data collection continues until delivery, and the primary outcome measured is the incidence of spinal anesthesia induced hypotension from anesthesia induction to delivery. The study is sponsored by Dow University of Health Sciences and runs until March 2025.

COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial