Actively Recruiting
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
Led by Dow University of Health Sciences · Updated on 2025-02-20
124
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension. The main questions it aims to answer are: Does norepinephrine lower the incidence of spinal anesthesia induced hypotension in emergency obstetrical patients? We will compare effectiveness of norepinephrine and phenylephrine for the prevention of spinal anesthesia induced hypotension. Participants will: Be administered prophylactic boluses of both drugs right after spinal anesthesia induction and maternal hemodynamic parameters and neonatal APGAR scores will be recorded
CONDITIONS
Official Title
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiologists physical status II or III patients
- Age between 18 and 40 years
- Pregnancy of 32 weeks gestation or more
You will not qualify if you...
- Hypertensive disorders of pregnancy with baseline systolic blood pressure over 160 mmHg or diastolic blood pressure over 99 mmHg
- Baseline mean arterial pressure less than 70 mmHg
- Antepartum hemorrhage or intraoperative blood loss greater than 1000 ml
- History of cardiovascular or neurological disease
- Known fetal abnormality
- Current use of serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors
- Maternal conditions requiring immediate general anesthesia
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology
Karachi, Sindh, Pakistan, 74200
Actively Recruiting
Research Team
R
Rabia Kamal, MBBS
CONTACT
A
Arsalan Jamil, FCPS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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