Dexmedetomidine as an Adjuvant in Peripheral Nerve Block.
Zheping Chen, Zhenzhen Liu, Chang Feng...
https://pubmed.ncbi.nlm.nih.gov/37220544Actively Recruiting
Phase 3
Age: 21Years - 65Years
FEMALE
ID06947330
Comparison Between Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy
Led by Kholoud Usama · Updated on 2025-04-27
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare two types of ultrasound-guided nerve blocks, the Erector Spinae Plane Block (ESPB) and the Serratus Anterior Plane Block (SAPB), in adult women undergoing Modified Radical Mastectomy for breast cancer. The study evaluates which block provides better pain relief and which is safer regarding risks like pneumothorax and hemodynamic changes. Both methods are being assessed to improve postoperative pain management after breast surgery. Participants will be randomly assigned to receive either the ESPB or SAPB block after anesthesia but before surgical incision. Each block involves injecting a combination of bupivacaine and dexmedetomidine guided by ultrasound to target specific nerve areas. Lung ultrasound will be performed before and after surgery to check for pneumothorax. Those who develop pneumothorax will be excluded and treated accordingly. The study includes a 24-hour follow-up period to monitor pain levels and additional pain medication use. During the study, participants will have their pain measured at multiple time points up to 24 hours after surgery using the Visual Analog Score (VAS). Researchers will also track total pain medication doses, duration of analgesia, vital signs, and the occurrence of pneumothorax. The study uses a double-blind design to ensure unbiased results. Overall participation spans the surgery day and the first postoperative day for close monitoring and data collection.
CONDITIONS
Brief Title
Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy
Who Can Participate
Age: 21Years - 65Years
FEMALE
Eligibility Criteria
You may qualify if you...
- ASA Physical Status II, or III.
- Age 21 - 65 years.
- Female gender
You will not qualify if you...
- ASA IV, V, VI.
- Infection at site of block.
- Coagulopathy, or patients on antiplatelets, or anticoagulants.
- Previous anesthetic allergy to bupivacaine.
- Distant organ metastasis.
- Male gender.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Surgery day and immediate postoperative period
Participants undergo modified radical mastectomy surgery with either Erector Spinae Plane Block or Serratus Anterior Plane Block for postoperative pain management.
1 surgical visit and assessments during hospital stay up to 24 hours postoperatively
Post-operative Follow-up
Duration - 24 hours postoperatively
Participants are monitored for pain levels, analgesic use, vital signs, and possible complications such as pneumothorax during the 24 hours following surgery.
Multiple assessments at 0, 2, 4, 6, 8, 16, 20, and 24 hours postoperatively
Trial Site Locations
Total: 1 location
1
Faculty of Medicine, Ain-Shams University
Cairo, Waili, Egypt, 0000
Actively Recruiting
Loading map...
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Comparison Between Erector Spinae Plane Block versus Serratus Anterior Plane Block Regarding Analgesia and Stress Response After Modified Radical Mastectomy: Randomized Controlled Trial.
Ahmed Abd Elmohsen Bedewy, Maged Salah Mohamed, Hesham Mohamed Sultan...
https://pubmed.ncbi.nlm.nih.gov/38741901