Actively Recruiting

Phase Not Applicable
Age: 18Years - 50Years
All Genders
ID07532161

Comparison Between Liquid Platelet-Rich Fibrin and Low-Level Laser Therapy on Healing and Relapse After Lip Repositioning Surgery

Led by Damascus University · Updated on 2026-04-29

22

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to compare the effects of Liquid Platelet-Rich Fibrin and Low-Level Laser Therapy on healing and relapse after lip repositioning surgery, a treatment for gummy smile caused mainly by upper lip hypermobility. The study addresses challenges such as pain, swelling, delayed healing, and relapse that can affect esthetic and functional outcomes. It explores whether these adjunctive techniques can improve healing and reduce relapse rates after surgery. Participants will be randomly assigned to one of two groups. One group will receive lip repositioning surgery followed by immediate injection of Liquid Platelet-Rich Fibrin along the incision margins. The other group will undergo the same surgery followed by application of low-level laser therapy immediately after surgery and on days 3, 7, 10, and 14 postoperatively. Both groups have similar surgical procedures but differ in the postoperative healing enhancement method. Participants will be monitored for gingival display at baseline and at 1, 3, and 6 months after surgery. Wound healing will be assessed weekly for 4 weeks. Other evaluations include postoperative pain, swelling, esthetic satisfaction, upper lip external and internal length, and any complications during and after surgery. The total involvement lasts at least 6 months with regular follow-ups to measure healing progress and relapse.

CONDITIONS

Brief Title

Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery

Who Can Participate

Age: 18Years - 50Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients of any gender
  • Age between 18 and 50 years
  • Presenting with gummy smile in the upper front teeth area due to upper lip hypermobility (more than 3 mm)
  • Generally healthy with no or mild well-controlled systemic conditions
  • Good oral hygiene with plaque index 40% or less
  • No previous lip repositioning surgery
Not Eligible

You will not qualify if you...

  • Pregnant or breastfeeding women
  • History of facial Botox or filler injections
  • Conditions that prevent safe use of local anesthesia
  • Physical issues preventing proper oral hygiene
  • Smokers or alcohol consumers
  • Unwilling or unable to cooperate
  • Inadequate width of attached gum tissue
  • Moderate to severe vertical maxillary excess needing jaw surgery
  • Short upper lip
  • Gingival display caused mainly by altered passive eruption needing crown lengthening

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - 1 day

Participants undergo lip repositioning surgery. Depending on the group, they receive either an immediate injection of Liquid Platelet-Rich Fibrin along the incision margins or low-level laser therapy applied to the surgical site immediately after surgery.

1 surgery visit (in-person)

Post-operative Follow-up

Duration - 2 weeks

Participants in the low-level laser group receive laser therapy at 3, 7, 10, and 14 days after surgery. Wound healing is assessed weekly for 4 weeks. Postoperative pain and swelling are monitored during the first week after surgery. Post-operative complications are evaluated in the first week.

5 visits (in-person) including days 3, 7, 10, and 14 post-surgery

Follow-up Monitoring

Duration - 6 months

Participants are followed to monitor gingival display, upper lip length, and esthetic satisfaction at 1, 3, and 6 months after surgery.

3 visits (in-person) at 1, 3, and 6 months post-surgery

Trial Site Locations

Total: 1 location

1

Faculty of Dentistry, Damascus university , Syria.

Damascus, Rif-dimashq Governorate, Syria

Actively Recruiting

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Research Team

T

Tarek Qasem, DDS MSc PhD

W

Walaa albarry, DDS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

A comparison between modified and conventional surgical techniques for surgical lip repositioning in the management of the gummy smile.

Asmaa Alammar, Omar Heshmeh, Radek Mounajjed...

https://pubmed.ncbi.nlm.nih.gov/30412347

Platelet-rich plasma (PRP) versus injectable platelet-rich fibrin (i-PRF): A systematic review across all fields of medicine.

Nima Farshidfar, Mohammad Amin Amiri, Nathan E Estrin...

https://pubmed.ncbi.nlm.nih.gov/40125556

A Modified Approach in Lip Repositioning Surgery for Excessive Gingival Display to Minimize Post-Surgical Relapse: A Randomized Controlled Clinical Trial.

Reham N AlJasser

https://pubmed.ncbi.nlm.nih.gov/36832213