Comparison Between a Rush and a Conventional Oral Immunotherapy Protocol to Treat Cow's Milk and Hen's Egg Allergy. CompITO Study Methodology.
Itziar Eusebio-Cartagena, Rodrigo Jiménez-Saiz, Vanesa Esteban...
https://pubmed.ncbi.nlm.nih.gov/41168926Actively Recruiting
Phase 2
Phase 3
Age: 6Years - 16Years
All Genders
ID06976775
Comparative Analysis Between Two Oral Immunotherapy Schemes in Cow´s Milk and/or Hen´s Egg Allergic Children to Improve Treatment Efficiency and Identify Response Biomarkers. CompITO Study
Led by Pablo Rodríguez del Rio · Updated on 2026-02-18
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates the efficacy and safety of two different OIT schemes to treat milk and egg allergic children
CONDITIONS
Brief Title
Comparison Between a Rush and a Conventional Oral Immunotherapy Protocol to Treat Cow's Milk and Hen´s Egg Allergy. CompITO Study
Who Can Participate
Age: 6Years - 16Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients 6 to 16 years old
- sIgE levels to milk 0.35 to 35kUA/L for milk allergic subjects and egg 0.35 to 35kUA/L for egg allergic subjects
- Entry DBPCFC discrete milk eliciting dose (ED)≥ 22.2mg of milk protein and discrete egg ED≥18.5mg of egg protein, that are the population-based reference values for the ED20
- Having a mild to moderate food allergy severity per DEFASE score (<13 points)
You will not qualify if you...
- sIgE levels to milk >35kUA/L for milk allergic subjects and egg > 35kUA/L for milk allergic subjects
- Entry DBPCFC discrete milk ED<22.2mg of milk protein or discrete egg ED<18.5mg of egg protein
- Entry DBPCFC discrete ED for milk>2112mg of milk protein (cumulative amount of 4193,7mg of milk protein) and egg discrete ED>1560mg of egg protein (cumulative amount of 3110.8mg of egg protein)
- Having severe food allergy per DEFASE score (≥13 points)
- Other exclusion criteria: uncontrolled asthma, FEV1<70%, severe atopic dermatitis, Eosinophilic Esophagitis, non-IgE mediated allergy, having started SCIT 3 months before, or SLIT one week before. Pregnancy
AI-Screening
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1
2
3
Trial Site Locations
Total: 1 location
1
Hospital Infantil Universitario Niño Jesús. Avenida de Menéndez Pelayo, número 65
Madrid, Spain, 28009
Actively Recruiting
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Research Team
D
Dr. Pablo Rodríguez del Río
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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