Actively Recruiting
Comparison Between Water Vapor Thermal Therapy and Prostatic Artery Embolization in Treatment of Benign Prostatic Hyperplasia
Led by Ain Shams University · Updated on 2026-02-18
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two procedures, Rezum therapy and Prostatic Artery Embolization, for men aged 50 and older with moderate-to-severe lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH). The study seeks to compare how well these treatments improve symptoms using the International Prostate Symptom Score (IPSS) over six months. It also looks at urine retention, urine flow rate, quality of life, and sexual function to guide treatment choices for men wanting alternatives to medication. Participants are randomly assigned to one of two groups. The Rezum group receives steam injections into the prostate using a special device under sedation or general anesthesia to heat and shrink prostate tissue. The Prostatic Artery Embolization group undergoes a minimally invasive procedure under local anesthesia where small particles are injected into arteries supplying the prostate to reduce its size. Both procedures involve specific catheter or needle techniques and imaging guidance. During the study, participants have a full medical evaluation including imaging and lab tests before treatment. Follow-up visits occur at 1, 3, and 6 months after treatment to assess symptoms and quality of life through questionnaires, urine flow tests, and ultrasound scans. Researchers monitor treatment effects, safety, and patient well-being throughout the study lasting at least six months per participant. Data on operative and post-operative outcomes will be analyzed to compare these two treatment methods.
CONDITIONS
Brief Title
Comparison Between Water Vapor Thermal Therapy and Prostatic Artery Embolization in Treatment of Benign Prostatic Hyperplasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 years or older
- International Prostate Symptom Score (IPSS) of 13 or higher
- Prostate volume between 30 and 80 milliliters
- Maximum urinary flow rate (Qmax) of 15 mL/sec or less in patients with voiding lower urinary tract symptoms
- Patients not responding to medical treatment
You will not qualify if you...
- History or suspicion of prostate cancer
- Previous prostate surgery or minimally invasive BPH intervention
- Neurological bladder dysfunction
- Active urinary tract infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment procedure
Participants receive either water vapor thermal therapy (Rezum) under sedation or general anesthesia, or prostatic artery embolization under local anesthesia to treat benign prostatic hyperplasia.
1 treatment visit (in-person)
Duration - 6 months
Participants are monitored to assess symptom improvement and treatment effects through questionnaires, uroflowmetry, and pelvic ultrasound.
Visits at 1, 3, and 6 months post-treatment
Trial Site Locations
Total: 1 location
1
Ain Shams University
Cairo, Abbassia, Egypt, 00202
Actively Recruiting
Research Team
S
Seif AbdElmomen Yosef, MBBCh, MSc Faculty of Medicine
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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