Study of Blood Pressure and Hormone Levels During Selective Adrenal Artery Embolization in Adults with Primary Aldosteronism and High Blood Pressure

What this Trial Is About

Researchers are investigating the relationship between blood pressure changes and catecholamine levels in the adrenal venous and peripheral venous blood of patients with primary aldosteronism PA who have high blood pressure and undergo percutaneous selective adrenal artery embolization SAAE. This study aims to understand why some patients experience large blood pressure spikes during SAAE while others do not, and to explore the possible mechanisms behind these blood pressure fluctuations caused by the treatment. The study involves collecting blood samples from two groups one from the adrenal vein and another from the peripheral vein in patients with PA undergoing SAAE. This minimally invasive procedure blocks blood flow to the affected adrenal gland to reduce excess aldosterone production. Blood pressure and hormone levels including norepinephrine, adrenaline, dopamine, renin, aldosterone, sodium, and potassium will be measured immediately and at intervals up to 30 minutes after embolization. The study will capture detailed blood pressure readings before and after the procedure using invasive and 24-hour monitoring. Participants will be monitored closely during the procedure with multiple blood and blood pressure measurements taken at specific times. Researchers will analyze changes in blood pressure and hormone levels to better understand the physiological effects of SAAE. The study is observational, following patients who meet strict diagnostic and blood pressure criteria for PA. Participants will provide informed consent and be observed until the study concludes at the end of 2026. The findings aim to improve knowledge about blood pressure control during this minimally invasive treatment for PA.

Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization