Effectiveness of Local Dexamethasone Injection Versus Oral Trypsin-Chymotrypsin to Reduce Pain and Swelling After Lower Wisdom Tooth Surgery

What this Trial Is About

This research aims to compare the effects of submucosal dexamethasone and oral trypsin-chymotrypsin on reducing common postoperative problems like pain, swelling, and difficulty opening the mouth after surgical removal of impacted lower third molars. These issues arise mainly from local inflammation after surgery. The study evaluates how these treatments work to control inflammation and improve recovery. Participants will receive one of two treatments a local injection of 8 mg dexamethasone given under the mucosa near the surgery site before the incision, or oral trypsin-chymotrypsin tablets taken starting 30 minutes before surgery and then three times daily for five days after extraction. The dexamethasone injection focuses the drug near the affected area with minimal systemic absorption, while the oral enzyme therapy aims to break down inflammatory peptides. Participants will be monitored for three months to compare how well each treatment reduces postoperative symptoms. Researchers will assess clinical signs of inflammation, including pain, swelling, and trismus. The study includes regular evaluations to track healing and any side effects. The trial uses a randomized design with single masking to ensure objective comparison of the two treatments.

Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery