Actively Recruiting
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Led by B.P. Koirala Institute of Health Sciences · Updated on 2024-12-03
50
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.
CONDITIONS
Official Title
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically healthy patients (ASA I) without systemic diseases affecting wound healing or surgery
- No recent use of anti-inflammatory drugs like NSAIDs, steroids, or antihistamines
- No allergy to the study drugs
- Need for surgical removal of impacted mandibular third molar
You will not qualify if you...
- Patients classified as ASA II to ASA VI
- Patients currently on corticosteroids by any route
- Known allergy to any drugs
- Pregnant or breastfeeding women
- Patients who do not consent to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bp Koirala Institute of Health Sciences
Dharān, Koshi, Nepal
Actively Recruiting
Research Team
S
sabin baniya, mds
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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