Actively Recruiting

All Genders
NCT06488872

Comparison of Computed Tomography Data With Routine Measurements Concerning Bone and Muscle Health of Aged Individuals

Led by University Department of Geriatric Medicine FELIX PLATTER · Updated on 2024-07-11

300

Participants Needed

1

Research Sites

69 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study focuses on researching sarcopenia and bone loss (osteoporosis), aiming to develop early and effective methods for diagnosis and treatment. These health issues significantly contribute to falls, fractures, and loss of independence and quality of life in old age, particularly affecting individuals impairments. To address these challenges, the study employs innovative imaging techniques based on artificial intelligence (AI) to accurately assess age-related muscle atrophy. A central approach is to analyze existing computed tomography (CT) images of older adults, using retrospective data to evaluate muscle quality. This method aims to efficiently assess muscle quality without additional resources. AI algorithms analyze fine details of muscle tissue, such as muscle adiposity and density. The algorithm can detect fat content within muscles, which negatively impacts muscle health and functionality, and identify irregularities or abnormalities in muscle fibers. This non-invasive approach is crucial for early detection of muscle atrophy and monitoring treatment success. Integrating AI technologies advances beyond conventional imaging techniques, allowing precise analysis of muscle quality. This method not only offers efficient diagnosis and monitoring of sarcopenia but also opens new avenues for personalized therapeutic approaches and improved patient care. Almost every elderly person has at least one existing CT scan, a common and excellent method of medical imaging for significant health issues. These images can be retrospectively analyzed for muscle health. In addition to imaging techniques, the study includes functional tests such as hand strength and walking speed measurements to assess muscle health and condition. These tests establish objective quality characteristics of muscles and assess the effectiveness of prevention and treatment measures. This research aims to provide early diagnosis and effective treatment strategies for sarcopenia and osteoporosis, ultimately improving the quality of life for the elderly. By leveraging AI and existing medical imaging data, the study promotes efficient, sustainable, and precise healthcare solutions for age-related muscle and bone deterioration.

CONDITIONS

Official Title

Comparison of Computed Tomography Data With Routine Measurements Concerning Bone and Muscle Health of Aged Individuals

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • CT scan images (thorax, abdomen, pelvis, spine) taken within one month before or after inpatient stay for sarcopenia assessment
  • CT thorax and abdomen images plus DEXA bone density scan performed within 18 months of each other for osteoporosis assessment
  • CT scans must have diagnostic image quality
Not Eligible

You will not qualify if you...

  • Documented refusal to participate
  • CT scans with non-diagnostic image quality
  • Missing functional test results for hand strength, timed up and go, or gait speed

AI-Screening

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Trial Site Locations

Total: 1 location

1

Universitäre Altersmedizin Felix Platter

Basel, Canton of Basel-City, Switzerland, 4055

Actively Recruiting

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Research Team

A

Andreas M. Fischer, PD Dr.

CONTACT

N

Natalie N Godau, Dr.

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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