Actively Recruiting
Comparison of Conservative and Endovascular Treatment for Spontaneously Isolated Superior Mesenteric Artery Dissection: A Real-world, Multicenter, Observational Study
Led by Xiangya Hospital of Central South University · Updated on 2022-04-22
200
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
X
Xiangya Hospital of Central South University
Lead Sponsor
T
The First Medical Center of Chinese PLA General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying Spontaneous Isolated Superior Mesenteric Artery Dissection (SISMAD), a condition increasingly diagnosed but with limited evidence guiding treatment. This observational study compares the effects of conservative treatment versus endovascular treatment to understand which approach better helps patients with this condition. The study is sponsored by Xiangya Hospital of Central South University and aims to provide real-world evidence to improve clinical decisions for SISMAD. Participants receive either endovascular treatments or conservative care. Conservative treatment includes managing blood pressure, bowel rest, antithrombotic therapy, nutritional support, and pain control. The study observes these treatment groups over time to assess outcomes without altering usual care. There is no randomization or blinding since this is an observational study. Participants will be followed for up to five years with regular monitoring of symptom relief and survival. Researchers will also track reintervention needs, recurrence, disease complications, and artery remodeling. Patients will undergo clinical evaluations and imaging to assess their condition's progress. The study involves long-term observation to gather comprehensive data on treatment effects and safety.
CONDITIONS
Brief Title
Comparison of Conservative and Endovascular Treatment for Spontaneously Isolated Superior Mesenteric Artery Dissection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 and above
- Diagnosed with isolated superior mesenteric artery dissection confirmed by CTA with clear symptoms or history
- Signed informed consent and willing to receive treatments
You will not qualify if you...
- Severe symptoms requiring exploratory laparotomy
- Having aortic dissection, iliac artery dissection, or autoimmune vasculitis
- Mental illness preventing cooperation
- Allergy to contrast agents or contraindications to conservative treatment drugs
- Pregnancy, breastfeeding, or recent plans to give birth
- Participation in other clinical trials
- Deemed unsuitable for participation by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants who undergo routine care for isolated superior mesenteric artery dissection are observed to compare outcomes between conservative and endovascular treatments.
Regular visits as per routine clinical care up to 5 years
Trial Site Locations
Total: 1 location
1
Xiangya Hospital of Central South University
Changsha, Hunan, China
Actively Recruiting
Research Team
W
Wang WEI, Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Frequently Asked Questions
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