Study Comparing Two Types of Breathing Support, CPAP and NIPPV, in Preterm Newborns with Respiratory Distress Syndrome

What this Trial Is About

Researchers are evaluating the safety and effectiveness of two non-invasive breathing support methods, Continuous Positive Airway Pressure CPAP and Non-Invasive Positive Pressure Ventilation NIPPV, in preterm newborns with respiratory distress syndrome. The study aims to compare how these methods perform in different gestational age groups, focusing mainly on the rate of treatment failure. Treatment failure includes severe breathing difficulties, respiratory acidosis, frequent apnea episodes, or worsening respiratory severity scores. The trial includes two groups of preterm infants receiving either CPAP or NIPPV. CPAP is provided at a pressure of 6-8 mmH2O, while NIPPV settings include specific pressures and breathing rates adjusted according to gestational age. The study will monitor the infants during their respiratory support to test if NIPPV results in fewer treatment failures and to compare complication rates between the two methods. Participants will be closely monitored for treatment failure within 7 days, as well as secondary outcomes like mortality, intubation, infection rates, and complications such as lung and nasal injuries. Researchers will assess these outcomes up to 44 weeks corrected gestational age. The study involves randomized assignment to treatment groups, with ongoing evaluations to track respiratory status and any side effects during the intervention period.

Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome.