Study Comparing Two Patient-Controlled Analgesia Methods for Postoperative Pain Management Variable-Rate Feedback Infusion Versus Fixed-Rate Basal Infusion After Mixed Surgery

What this Trial Is About

Researchers are evaluating different patient-controlled analgesia PCA strategies to improve pain management after various types of surgery. The study focuses on comparing fixed-rate basal infusion with a variable-rate feedback infusion to see if opioid use can be reduced while providing better pain relief and fewer side effects. This research aims to support personalized and smarter pain control during recovery and reduce complications linked to excessive opioid use. Participants receive a standardized PCA solution containing sufentanil, ondansetron, and saline. One group uses a fixed-rate basal infusion delivering a set dose continuously, while the other group uses a variable-rate feedback infusion that adjusts the dose based on patient demand, increasing or decreasing the background infusion rate accordingly. These methods are assessed over 48 hours after surgery to determine their impact on opioid consumption and pain control. Throughout the study, participants will be monitored for total opioid use at 48 hours post-surgery, pain scores at rest and during movement at multiple time points, use and dosage of additional rescue pain medications, quality of recovery and sleep, sedation levels, nausea and vomiting, and satisfaction with PCA. The study includes regular assessments within the first 48 hours to gather detailed safety and effectiveness data, helping researchers understand how these PCA methods influence postoperative recovery.

Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery