Prospective Randomized Controlled Study Comparing Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous Patient-Controlled Analgesia After Mixed Surgery

What this Trial Is About

Perioperative pain management plays a crucial role in patient recovery after surgery, yet many patients experience moderate to severe pain, which delays healing and raises complication risks. This research investigates different patient-controlled analgesia (PCA) strategies to manage pain better while aiming to reduce opioid use and related side effects. The study compares traditional fixed-rate PCA with a variable-rate feedback infusion mode to provide evidence for more personalized and adaptive pain control methods during postoperative care. Participants will receive a standardized PCA solution containing sufentanil, ondansetron, and saline. One group will use a fixed-rate basal infusion delivering a steady dose, while the other group will use a variable-rate feedback infusion that adjusts the opioid dose based on patient demand. The variable-rate allows increases or decreases in the background infusion depending on pain needs, with limits set for safety. This approach aims to improve pain relief while minimizing opioid consumption. Throughout the study, patients' opioid use will be closely monitored for 48 hours post-surgery. Pain levels at rest and movement, PCA usage volume, additional rescue medication needs, quality of recovery and sleep, sedation levels, nausea, and patient satisfaction will be assessed at various intervals within the first two days. The study uses a randomized, quadruple-blind design to ensure unbiased results and will provide detailed safety and effectiveness data to support improved postoperative pain management.

Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery