Actively Recruiting
Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation
Led by Medical University of Graz · Updated on 2026-02-18
26
Participants Needed
1
Research Sites
278 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether jawbone augmentations using two types of bone blocks, allogeneic (donor bone) and autogenous (patient's own bone), result in similar three-dimensional clinical and radiological outcomes. The study also aims to compare safety, biocompatibility, complications, and patient-reported outcomes. Additionally, it investigates differences in implant condition one year after implantation and during annual follow-ups for up to five years. The study involves two treatment groups: one receiving customized allogenic bone block augmentation designed with 3D technology based on the patient's CT/CBCT scans, covered with a collagen-based membrane; and the other receiving autologous bone block grafts adapted to the defect site and immobilized with screws, sometimes supplemented with bone particles. Both procedures target patients with insufficient bone volume to allow standard implant placement. Participants will be followed over several years with evaluations of ridge width gain measured at multiple time points, including screening, 180 days after augmentation, and annually for up to five years after the second stage surgery. Researchers will monitor clinical and radiological outcomes, implant conditions, and patient experiences throughout the study period. The total participation duration extends up to five years after implantation to assess long-term results.
CONDITIONS
Brief Title
Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have 1 to 4 missing teeth that need to be replaced with dental implants
- Have bone ridge width less than 5 mm at the implant site as measured by cone beam computed tomography
- Are medically healthy with no known allergies to antibiotics
- Are a non-smoker, light smoker (less than 10 cigarettes per day), or former smoker who quit at least 5 years ago
- Have periodontal health confirmed by clinical examination with bleeding and plaque scores less than 25% and at least one neighboring natural tooth
- Are 18 years old or older
You will not qualify if you...
- Have contraindications to implant treatment or bone augmentation such as advanced systemic diseases, corticosteroid use, immunodeficiency, pregnancy, breastfeeding, or lack of safe contraception
- Have treatments or diseases affecting bone turnover or metabolism such as bisphosphonate use, local radiotherapy, or skeletal immaturity
- Have pathological fractures from diseases like Paget's disease or metastatic bone disease
- Have any active cancer or are undergoing cancer treatment
- Are allergic or hypersensitive to the study drugs or investigational products
- Have persistent compartment syndrome or neurovascular problems related to it
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo alveolar ridge augmentation surgery using either customized allogenic or autogenous bone block grafts to increase bone volume for implant placement.
1 surgical visit
Duration - Up to 5 years
Participants are monitored after surgery to assess healing and ridge width gain at multiple timepoints.
Visits at 180 days post-augmentation, 1 year, 2 years, 3 years, 4 years, and 5 years after 2nd stage surgery
Trial Site Locations
Total: 1 location
1
Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz
Graz, Styria, Austria, 8010
Actively Recruiting
Research Team
M
Michael Payer, Assoz.Prof.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here