Study of Cytokine Changes in Eye Fluid and Tears Before and After Ultrasound Cyclo Plasty Treatment for Glaucoma

What this Trial Is About

Glaucoma is a leading cause of irreversible vision loss in people aged 50 years and older worldwide, second only to cataracts. Researchers are studying Ultrasound Cyclo Plasty UCP, a minimally invasive technique targeting the ciliary body to regulate intraocular pressure IOP. This study aims to analyze changes in cytokines in the eyes aqueous humor after UCP to better understand their role in surgery outcomes and improve predictability of the procedures success in patients with primary glaucoma. The treatment involves the use of the EyeOP1 device to perform UCP. During the procedure, a coupling cone is placed on the eye, secured with vacuum suction, and filled with balanced salt solution for ultrasound transmission. Ultrasound transducers emit energy at 21 MHz with controlled power and timing to target the ciliary body precisely. The study observes matched eyes of glaucoma patients before and after treatment to compare cytokine profiles and other eye parameters. Participants will be monitored over an average of two years, during which researchers will measure cytokine levels in aqueous humor, intraocular pressure, and anterior segment parameters. Additional evaluations include visual acuity and recording any complications. The study collects tear samples for follow-up, and data on the eyes environment changes post-treatment to assess the surgerys effects and safety over time.

Comparison of Cytokines Profile in Aqueous Humor and Tear Before and After UCP Treatment