Comparative Study Between Demineralized and Mineralized Allogeneic Dentin Grafts for Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial

What this Trial Is About

Researchers are evaluating how two types of allogeneic dentin grafts—demineralized and mineralized—affect bone preservation after the extraction of a single upper back tooth. This trial involves 45 patients divided into three groups: one with no graft for natural healing, one using a demineralized dentin graft, and one using a mineralized dentin graft. The study aims to provide evidence to help dentists choose the best grafting approach for preserving the alveolar ridge before implant placement. The treatments involve placing the graft material into the tooth socket immediately after an atraumatic extraction. The demineralized graft is a collagen-rich matrix exposing growth factors to stimulate bone growth, while the mineralized graft retains the mineral content to provide structural support and slower bioactive molecule release. Both grafts are covered with a resorbable collagen dressing and the site is closed. The control group receives no graft and heals naturally. The study lasts six months, allowing detailed comparison of how each approach supports ridge preservation. Participants will have their ridge width, height, and bone density measured at the time of extraction and six months later using CBCT imaging. Additional assessments include patient-reported pain and swelling shortly after surgery, satisfaction with treatment, keratinized tissue width, and bone biopsy analysis at implant placement. Follow-up visits will monitor healing and outcomes to determine which graft type better maintains bone structure and supports future dental restoration.

Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation