Actively Recruiting
Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation
Led by Kafrelsheikh University · Updated on 2025-11-24
45
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
Sponsors
K
Kafrelsheikh University
Lead Sponsor
N
National Research Centre, Egypt
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.
CONDITIONS
Official Title
Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- Medically healthy patients classified as ASA I
- Single non-restorable tooth indicated for extraction in the posterior maxilla
- Adequate oral hygiene with plaque and bleeding indices below 20%
- Sufficient bone volume for socket preservation without simultaneous augmentation
- Willingness to participate and provide written informed consent
- Ability to attend follow-up visits for up to 6 months
You will not qualify if you...
- Current smokers or tobacco users
- Uncontrolled systemic diseases such as uncontrolled diabetes
- Conditions affecting bone metabolism including osteoporosis or long-term corticosteroid use
- Pregnant or lactating women
- History of radiotherapy in the head and neck area
- Active infection or pus at the extraction site
- Immunocompromised status or use of immunosuppressive therapy
- Use of medications that impair healing like bisphosphonates
- Allergy or hypersensitivity to any study materials
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Dentistry, Kafrelsheikh University
Kafr ash Shaykh, Egypt
Actively Recruiting
Research Team
A
Ahmed Abdelaziz, BDS, MSc candidate
CONTACT
E
Enas Elgendy, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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