Comparison of Different Doses of Dexmedetomidine Combined With Ketamine for Post-Operative Pain Control in Cesarean Section Surgeries

What this Trial Is About

This research aims to compare three different doses of dexmedetomidine combined with a fixed dose of ketamine for pain control in women undergoing cesarean section. It seeks to identify the most effective combination that provides good pain relief with the fewest side effects. The study focuses on managing postoperative pain, which can affect recovery, mother-child bonding, psychological well-being, and nursing after cesarean delivery. Participants will receive one of three continuous intravenous infusions during the postoperative period: dexmedetomidine at 0.2, 0.3, or 0.4 g/kg/hr combined with ketamine at a fixed dose of 0.25 mg/kg/hr. This combination is being studied because it may offer better pain relief with fewer opioid-related side effects, such as respiratory depression and nausea. The study will monitor the effects of these dosing regimens to determine optimal pain management. During the study, women's postoperative pain will be assessed using pain scores over the first 24 hours after surgery. Researchers will also track the time until first additional pain medication is needed and the total amount of rescue analgesia used within 24 hours. Safety and side effects will be monitored, and participants' responses will help guide improved protocols for pain control after cesarean section. The total participation period covers the immediate 24-hour postoperative phase.

Comparison of Dexmedetomidine + Ketamine for Postoperative Pain in C-Section