Evaluating Diagnostic Methods for Cytomegalovirus Organ Disease in Adults with Inflammatory Bowel Disease Experiencing Symptom Worsening

What this Trial Is About

This research focuses on adult patients with Inflammatory Bowel Disease IBD who experience worsening symptoms requiring hospitalization. It aims to evaluate different diagnostic methods for detecting cytomegalovirus CMV organ disease in the intestines, a condition that can be challenging to identify due to overlapping symptoms and immune system changes related to IBD and its treatments. The study compares new diagnostic tools against the current gold standard to improve early detection and management. Participants will undergo colonic biopsies to confirm or exclude CMV organ disease. The study compares the performance of CMV-DNA testing in blood and fecal samples with immunohistochemical analysis of biopsy tissue. These diagnostic tests are observed over an average of two years to assess their accuracy and usefulness in clinical practice. Throughout the study, participants will be monitored for clinical outcomes and diagnostic results. Researchers will evaluate the severity of CMV infection patterns, viral load in biopsy samples, and the impact of antiviral treatments on disease progression. Follow-up assessments include a 30-day clinical evaluation, with ongoing monitoring until study completion, lasting approximately two years.

Comparison Diagnostic Tests for the Diagnosis of CYTOmegalovirus Organ Disease in Patients With intestinalBOweL Diseases