Actively Recruiting
Comparison of Different Cerebrospinal Fluid Sampling Sites on External Ventricular Drains
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-07-01
55
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare cerebrospinal fluid (CSF) samples taken from two different sites on external ventricular drains (EVDs) used in patients with conditions such as brain bleeding, head trauma, or tumors. The goal is to see if sampling CSF distally (farther from the brain) provides similar results to proximal sampling (closer to the brain). If proven similar, distal sampling could reduce risks like infection or brain injury associated with proximal sampling. Patients with EVDs currently undergo routine CSF sampling two to three times a week to monitor protein, glucose, lactate levels, and cell counts, helping detect infections and guide treatment decisions. This study evaluates CSF collected both proximally, near the brain, and distally, near the collection bag, to assess differences. Distal sampling may lower risks and allow nurses or other physicians to perform sampling instead of neurosurgeons. Participants will have CSF samples collected every 2-3 days from the time the EVD is placed until it is removed, estimated between 7 and 28 days. Researchers will analyze and compare white and red blood cell counts, protein, glucose, lactate levels, cultures, and gram stains from both sampling sites over time. Safety concerns like infections or new bleeding events related to sampling will also be monitored throughout the study duration.
CONDITIONS
Brief Title
Comparison of Different CSF Sampling Sites on External Ventricular Drains
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with an external ventricular drain (EVD) in place regardless of the underlying condition
- Written informed consent obtained from the patient or a legally authorized representative
- If the patient can consent but cannot sign, an impartial witness can attend the consent process
- Males and females of all ages, including children and pregnant females
You will not qualify if you...
- Patients scheduled to have their external ventricular drain removed within 48 hours before routine sampling can be done
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 7 to 28 days
Participants with external ventricular drains have cerebrospinal fluid (CSF) samples collected every 2 to 3 days from two different sites on the drain to compare sample characteristics and assess safety.
Sampling visits every 2 to 3 days until removal of the external ventricular drain
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
P
Philippe De Vloo, prof.dr.
T
Tom Deleu, dr.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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