Comparison of Different Methods to Calculate Pendelluft by Electrical Impedance Tomography in Patients Undergoing Invasive Mechanical Ventilation Under Pressure Support Mode

What this Trial Is About

This research aims to study the Pendelluft phenomenon, a cause of lung damage in patients who are mechanically ventilated and breathing on their own. The study focuses on comparing different methods to measure the stress Pendelluft causes on lung tissue, using electrical impedance tomography. It explores how regional lung volume and local pressure contribute to lung overstress during invasive ventilation in pressure support mode. Patients will undergo variations in pressure support levels during invasive mechanical ventilation. They will be monitored first at their usual clinical pressure support for about 30 minutes, then at 50% lower and 50% higher pressure support levels in a randomly assigned order. During each phase, blood gas samples will be collected, and specific inspiratory and expiratory pauses will be performed to record pressures and estimate lung mechanics. The collected data will be analyzed later to compare different Pendelluft measurement methods. Participants will have respiratory mechanics monitored through electrical impedance tomography and esophageal/gastric pressure measurements. The study involves recording lung function and collecting blood samples at each pressure level, with pauses to capture plateau pressures. Researchers will measure Pendelluft magnitude and respiratory effort during these periods. The protocol includes safety monitoring, and ventilator settings will be returned to baseline after testing. Total participation time includes multiple 30-minute monitoring sessions under different pressure supports.

Comparison of Different Methods to Calculate Pendelluft by Electrical Impedance Tomography in Mechanically Ventilated Patients