Actively Recruiting
Comparison of Distal IPACK and Popliteal Plexus Block Combined With Femoral Triangle Block After Total Knee Arthroplasty
Led by Karaman Training and Research Hospital · Updated on 2026-04-28
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of combining femoral triangle block with either popliteal plexus block or distal IPACK block to manage pain after total knee arthroplasty (TKA). The study compares these two nerve block techniques, which target nerves supplying the back of the knee, as part of a multimodal pain relief approach. This research addresses an important question about which combination may better reduce pain and opioid use after knee replacement surgery. The trial involves two groups receiving different combinations of nerve blocks: one group gets femoral triangle block with popliteal plexus block, and the other gets femoral triangle block with distal IPACK block. Each block is given as a single dose bolus of 10 ml of 5% bupivacaine. These procedures are applied during spinal anesthesia before the knee replacement surgery. Participants will be monitored for opioid consumption during the first 24 hours after surgery, which is the main outcome measured. Secondary assessments include pain scores, knee movement range, patient mobilization, muscle strength tests before and after blocks, incidence of rebound pain, and quality of recovery over 48 hours. Muscle strength is evaluated at several time points using standardized tests. The study lasts through the early postoperative period to understand pain control and function following the nerve blocks.
CONDITIONS
Brief Title
Comparison of Distal IPACK and Popliteal Plexus Block Combined With Femoral Triangle Block After Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing total knee arthroplasty under spinal anesthesia
- American Society of Anesthesiologists (ASA) status I-III
- Patients who give informed consent
- Age between 18 and 85 years
You will not qualify if you...
- Patients unable to cooperate
- Kidney disease with GFR < 50 ml/min
- Daily opioid consumption for more than 1 month
- Allergy to local anesthetics
- Neurological problems of the lower extremity
- Contraindications to peripheral nerve blocks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day around the time of surgery
Participants receive either a femoral triangle block combined with a popliteal plexus block or a femoral triangle block combined with a distal IPACK block as part of their knee surgery anesthesia.
1 visit (in-person, on surgery day)
Duration - Up to 48 hours post-surgery
Participants are monitored for pain relief, muscle strength, and recovery after surgery.
Assessments during 1 to 2 visits within 48 hours post-surgery
Trial Site Locations
Total: 1 location
1
Karaman Training and Research Hospital, Karaman, Karaman 70200
Karaman, Turkey (Türkiye), 70200
Actively Recruiting
Research Team
T
Tayfun Et
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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