Actively Recruiting
Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids
Led by Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan · Updated on 2026-04-24
88
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how well intralesional 5 fluorouracil with cryotherapy works to treat keloids as compared to intralesional 5 fluorouracil alone on keloids. It will also learn about the safety of both these treatments. The main questions it aims to answer are: * What well does cryotherapy followed by intralesional 5 fluorouracil (5FU) work to treat keloids as compared to 5 fluorouracil (5FU) alone? * What is participant's satisfaction when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) as compared to 5 fluorouracil (5FU) alone? * What skin problems do participants have when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) and 5 fluorouracil (5FU) alone? Researchers will compare cryotherapy followed by intralesional 5 fluorouracil (5FU) with 5 fluorouracil (5FU) alone to see how well both work. Participants will be divided into two groups: For Group A: Cryotherapy will be done at lesion site followed by intralesional 5FU every 3 weekly. For Group B: Intralesional 5FU will be given at lesion site every 3 weekly. Keloids will be assessed at the start of trial and then after 12 weeks of treatment.
CONDITIONS
Official Title
Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients willing to participate in the study
- Patients aged 18 to 50 years
- Patients with symptomatic keloids causing pain, itching, movement restriction, scar tension, or disfigurement
You will not qualify if you...
- Pregnant or lactating women
- Patients with liver, kidney, or heart disease or chronic diarrhea
- Patients using immunosuppressant medications
- Patients with myelosuppression as checked by CBC
- Patients taking warfarin
- Patients with hypersensitivity to 5 fluorouracil
AI-Screening
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Trial Site Locations
Total: 1 location
1
CMH Bahawalpur
Chak Four Hundred Fifty-four, Pakistan
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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