Actively Recruiting
Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression
Led by Ataturk University · Updated on 2025-12-04
60
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In recent years, research on the effectiveness of transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (RTD) has been steadily increasing. The aim of this study was to examine the effectiveness of accelerated unilateral application of two different forms of theta burst stimulation (TBU), a variation of repetitive TMU (rTMS)-intermittent TBU (iTBU) and continuous TBU (cTBU)-in TDD patients. The study aimed to compare the advantages of iTBU and cTBU protocols on depression, suicidal thoughts, anxiety levels, sleep disturbances, cognitive performance, and overall functioning following a two-week intensive treatment period and a 12-week follow-up period.
CONDITIONS
Official Title
Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Diagnosed with Major Depressive Disorder according to DSM-5
- Scoring 7 points or more on the Maudsley staging method
- Depression not responding to at least two different antidepressants
- No clinical mental retardation
- Agree to participate in the study
- Hamilton Depression Rating Scale-17 score of 20 or higher
- Montgomery Asberg Depression Rating Scale score of 20 or above
- Right hand dominant
- Using the same antidepressant at the same dose for the last 4 weeks
You will not qualify if you...
- Diagnosed with neurological or metabolic diseases affecting cognitive functions (e.g., diabetes, cardiovascular disease, cerebrovascular disease, chronic renal failure, Parkinson's disease, multiple sclerosis, polyneuropathy, inflammatory rheumatologic disease, malignancies)
- Having a pacemaker or intracranial implant that interacts magnetically
- Hearing or visual impairments preventing communication
- Unstable or acute medical conditions
- Pregnancy or breastfeeding
- Having a primary psychiatric disorder other than major depressive disorder
- Diagnosed with severe major depressive disorder with psychotic features
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ataturk University
Erzurum, Turkey (Türkiye), 25240
Actively Recruiting
Research Team
M
Mahmut Balamur, research assistant doctor
CONTACT
O
Omer Faruk UYGUR, Associate professor doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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