Completed
Comparison of Efficacy and Safety of Psoriatic Nails Treatment Between by Intralesional 0.1%Triamcinolone Injection and Topical 0.05%Clobetasol Propionate Ointment
Led by Mahidol University · Updated on 2012-10-10
16
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Psoriatic nails can significantly affect a quality of life of patients. Psoriasis affects both nail matrix and nail bed. Pitting, leukonychia and red spots in lunula indicate a defect in the nail matrix. Psoriasis can change the nail bed as the results in onycholysis, discoloration, splinter hemorrhage and subungual hyperkeratosis. The main treatment of psoriatic nails is using topical high- potent steroids however topical steroids are limited their ability to penetrate deep nail matrix or nail bed which are the main pathology. Use of such a treatment can lead to skin atrophy and report in the case of "Disappearing digits". Previous studies of steroid injection in the treatment of psoriatic nails show satisfactory results without any serious permanent adverse effects. At present, there is no comparison study between intralesional steroid and ultrapotent topical steroid for the treatment of psoriatic nails. The purpose of the study is to evaluate the efficacy and safety of intralesional triamcinolone comparing to 0.05% clobetasol ointment in the treatment of psoriatic nails.
CONDITIONS
Official Title
Comparison of Efficacy of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged over 18 years old who have at least 3 psoriatic finger nails resembly severity
You will not qualify if you...
- Patients are receiving the systemic therapy of psoriasis
- Patients discontinued the systemic therapy less than 3 months and topical therapy less than 1 month
- Positive results for the microscopic study of fungus in finger nails
- History of steroids or EMLA allergy
- Pregnancy or nursing
- Any skin infection at the site of the treatment
- Human immunodeficiency virus subjects
- History of malignancy or during the treatment of malignancy
- Patients who have psychological disorder
- Patients who have bleeding disorder or receiving anticoagulation drugs
Trial Site Locations
Total: 1 location
1
Siriraj Hospital
Bangkok, Bangkok, Thailand, 10700
Status Unknown
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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