Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID07043335

Comparison of the Efficacy of Mesotherapy and Extracorporeal Shock Wave Therapy in Patients With Lateral Epicondylitis: A Prospective Randomised Controlled Trial

Led by Haydarpasa Numune Training and Research Hospital · Updated on 2026-02-18

50

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effectiveness of mesotherapy compared to extracorporeal shock wave therapy (ESWT) in treating patients with lateral epicondylitis, also known as tennis elbow. This randomized-controlled, single-blind study includes patients aged 18 to 65 years who have experienced elbow pain for at least six weeks. The study aims to determine whether mesotherapy is as effective as ESWT in relieving pain and improving function in this condition. Participants will be randomly assigned to one of two groups. Group 1 will receive mesotherapy injections consisting of lidocaine, pentoxifylline, thiocolchicoside, and meloxicam delivered intradermally using a fine needle at painful elbow points, with five sessions given once weekly. Group 2 will receive five weekly sessions of ESWT applied to the lateral epicondyle area with specified frequency, energy density, and pulse count. All participants are advised to use resting wrist splints and perform exercises. During the trial, participants will be assessed before treatment, 30 minutes after treatment completion, and again 12 weeks later. Evaluations include pain severity using the Visual Analogue Scale (VAS), functional impairment via the Patient-Rated Tennis Elbow Evaluation, and quality of life through the SF-12 Health Survey. Additional measurements include pressure-pain threshold and grip strength. Demographic and clinical data will be recorded, and safety and treatment effects will be monitored throughout the study duration.

CONDITIONS

Brief Title

Comparison of the Efficacy of Mesotherapy and Extracorporeal Shock Wave Therapy in Patients With Lateral Epicondylitis

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged between 18 and 65 years
  • Pain and tenderness in the unilateral lateral epicondyle for 6 weeks
  • Clinically diagnosed with Lateral Epicondylitis
  • Patients without cognitive deficits who can follow verbal instructions
Not Eligible

You will not qualify if you...

  • Receiving an interventional injection in the elbow region within the last 3 months
  • Receiving physical therapy in the last 3 months
  • Receiving regular nonsteroidal anti-inflammatory drug (NSAID) treatment in the last 2 weeks
  • History of fracture or surgery in the affected elbow region
  • Chronic inflammatory diseases
  • Acute infection
  • History of malignancy
  • Coagulation disorders
  • Pregnancy
  • Presence of a pacemaker or electronic implants
  • Cervical radiculopathy and entrapment neuropathy
  • Drug allergies
  • BMI > 35

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 5 weeks

Participants receive one of two treatments for lateral epicondylitis: Mesotherapy injections or Extracorporeal Shock Wave Therapy. Both treatments consist of 5 sessions given once every 7 days. Exercise and resting wrist splints are recommended for all participants.

5 weekly visits (in-person)

Follow-up

Duration - 7 weeks

Participants are assessed to evaluate treatment effects and recovery at 12 weeks after treatment completion.

1 follow-up visit (in-person)

Trial Site Locations

Total: 1 location

1

Health Science University Haydarpasa Numune Research and Training Hospital, Istanbul, Uskudar 34668

Istanbul, Turkey (Türkiye)

Actively Recruiting

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Research Team

B

Berna Gunay, Medical doctor

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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