Comparison of Fixed-rate Basal Infusion and Time-programmed Decremental Background Infusion Modes for Intravenous Patient-Controlled Analgesia After Mixed Surgery

What this Trial Is About

Researchers are studying pain management after surgery, focusing on how to improve recovery by controlling pain more effectively. Despite opioids being commonly used, many patients experience moderate to severe pain after surgery, which can slow recovery and increase complications. This study compares two different patient-controlled analgesia (PCA) methods to see if one can reduce opioid use, improve pain relief, and lower side effects. The goal is to support personalized and smarter pain management after surgery. Participants receive one of two PCA treatments using a standardized solution with sufentanil and ondansetron. One group gets a fixed-rate infusion delivering a steady dose continuously. The other group follows a time-programmed decreasing infusion, where the infusion rate reduces stepwise over 48 hours to match expected pain changes. Both groups can self-administer doses as needed with a lockout interval to limit overdose. During the first 48 hours after surgery, researchers will track total opioid use, pain levels at rest and during movement, and use of any extra pain medications. They will also assess patients' recovery quality, sleep, sedation, nausea, and satisfaction with the PCA device. These measures will be taken at multiple time points to monitor effects and safety. The study runs from surgery through the first two postoperative days to gather comprehensive data on pain control approaches.

Comparison of the Efficacy and Safety of Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode of Intravenous PCA Following Mixed Surgery