Safety and Effectiveness of Manual Syringing Versus Pneumatic Pressure Bag for Blood Transfusion in Women Undergoing Cesarean Section With Major Obstetric Hemorrhage

What this Trial Is About

Researchers are evaluating the safety and effectiveness of two methods for blood transfusion in women experiencing major obstetric hemorrhage during cesarean sections. The study focuses on comparing manual syringing using 20 mL syringes and pneumatic pressure bags inflated to 300 mmHg. The main goals include assessing which method causes more red blood cell destruction hemolysis, which stabilizes vital signs faster, and differences in blood product usage, complications, and hospital stay length. The trial is a prospective, randomized controlled study conducted at a single center. Women aged 18 to 45 undergoing cesarean section with major hemorrhage are randomly assigned to receive blood transfusions via manual syringing or pneumatic pressure bags. All participants have vascular access through multiple cannulae and are closely monitored for vital signs and transfusion-related complications. Blood samples are collected at baseline and six hours after transfusion to check markers of hemolysis. Participants undergo continuous monitoring of blood pressure, heart rate, and oxygen levels to determine the time to hemodynamic stability. Researchers track transfusion complications during hospitalization and for 30 days after surgery. The study measures primary outcomes such as hemolysis incidence using laboratory markers and secondary outcomes including hemodynamic stability achievement, blood volume transfused, and complications. The total participation duration includes the treatment period and postoperative follow-up for safety.

Comparison of Efficacy and Safety of Manual Syringing Versus Pneumatic Pressure Bag for Blood Transfusion in Patients Undergoing Cesarean Section With Major Obstetric Hemorrhage