Actively Recruiting
Comparison of Extracorporeal Shock Wave Therapy and Ultrasound-Guided Ozone Injection Therapy for Resistant Lateral Epicondylitis
Led by Ankara City Hospital Bilkent · Updated on 2026-02-23
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Lateral epicondylitis is a painful condition affecting the outer part of the elbow, often becoming chronic and resistant to standard treatments. This trial compares two treatments for patients with chronic, treatment-resistant lateral epicondylitis: Extracorporeal Shock Wave Therapy (ESWT) and ultrasound-guided ozone injection. The study aims to evaluate which treatment offers better clinical and structural improvements for patients suffering from this condition. Participants will be randomly assigned to either the ESWT group or the ozone injection group. The ESWT group will receive shock wave therapy once a week for three weeks, with each session delivering 2000 impulses targeted to the affected tendon. The ozone injection group will receive an oxygen-ozone gas mixture injected under ultrasound guidance into the tendon once weekly for three weeks. Both treatments follow their standard protocols. Throughout the study, participants will be assessed at three times: before treatment, immediately after the 3-week treatment period, and at a 4-week follow-up. Researchers will measure pain using the Visual Analog Scale (VAS), function with the Patient-Rated Tennis Elbow Evaluation (PRTEE), grip strength with a dynamometer, and tendon changes via high-resolution ultrasound. These assessments help determine treatment effects and monitor safety during the trial period.
CONDITIONS
Brief Title
Comparison of ESWT and Ultrasound-Guided Ozone Injection in Lateral Epicondylitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients between 18 and 65 years old
- Diagnosed with lateral epicondylitis lasting more than 3 months
- Increased pain on palpation of the lateral epicondyle and positive provocation tests
- Lack of response to first-line conservative treatments like analgesics, exercise, rest, or splinting
- No other pathology detected on elbow X-rays
- No corticosteroid injection to the affected elbow within the last 6 months
- Voluntary participation in the study
You will not qualify if you...
- Presence of elbow problems other than lateral epicondylitis (e.g., loose bodies, rheumatoid nodules)
- Previous surgery on the affected elbow joint
- Tendon rupture present
- Unwillingness to continue treatment or participate
- Cervical root pathology or cervical radiculopathy
- Diagnosed upper extremity entrapment neuropathy
- Neurological impairment or deficits
- Injection therapy to the elbow within the last 6 months
- Physical therapy for the elbow within the last 6 months
- Pregnancy
- Coagulation or bleeding disorders
- Peripheral vasculopathy
- Complex Regional Pain Syndrome (CRPS)
- History of malignancy
- Systemic inflammatory or autoimmune disorders
- History of direct trauma to the elbow
- Current use of medications affecting pain or muscle strength
- Open wounds, infection, or active inflammation in the elbow
- Difficulty cooperating or cognitive inability to follow instructions
- Congenital Glucose-6-Phosphate Dehydrogenase deficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 weeks
Participants receive either extracorporeal shock wave therapy or ultrasound-guided ozone injection therapy targeted at the affected tendon.
1 visit per week for 3 consecutive weeks (in-person)
Duration - 4 weeks
Participants are monitored after treatment to assess symptom improvement and tendon healing.
1 follow-up visit 4 weeks after treatment completion
Trial Site Locations
Total: 1 location
1
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye)
Actively Recruiting
Research Team
D
Duygu Elbaşı, Medical Doctor
B
Berke Aras, Medical Doctor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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