Actively Recruiting
Comparison of FCV and VCV in One-Lung Ventilation
Led by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Updated on 2026-02-06
60
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
Sponsors
D
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Lead Sponsor
K
Kocaeli City Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters remain an important clinical concern. Flow-controlled ventilation (FCV) is a newer ventilation mode that allows precise control of inspiratory and expiratory flow, potentially improving lung mechanics and gas exchange. Volume-controlled ventilation (VCV) is a widely used conventional ventilation strategy during thoracic anesthesia. The FCVOLVent study is a multicenter, prospective observational study designed to compare the effects of FCV and VCV during one-lung ventilation in adult patients undergoing thoracic surgery. Patients will be ventilated with either FCV or VCV as part of routine clinical practice. The study aims to evaluate respiratory mechanics and oxygenation parameters, including the PaO₂/FiO₂ ratio, airway pressures, lung compliance, and mechanical power during surgery. Data will be collected at predefined time points during one-lung ventilation. The results of this study are expected to provide real-world clinical evidence on the potential advantages and limitations of flow-controlled ventilation compared with volume-controlled ventilation during one-lung ventilation.
CONDITIONS
Official Title
Comparison of FCV and VCV in One-Lung Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years and older
- Undergoing thoracic surgery requiring one-lung ventilation (OLV)
- One-lung ventilation required for at least 30 minutes
- American Society of Anesthesiologists (ASA) physical status I-III
- Provided written informed consent
- Ventilated with either flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine care
You will not qualify if you...
- Emergency surgery required
- History of untreated asthma
- High pulmonary risk with predicted postoperative FEV1 less than 20 mL/kg in males or less than 18 mL/kg in females
- High cardiac risk including advanced cardiomyopathy with left ventricular ejection fraction less than 30%
- Body mass index (BMI) greater than 35 kg/m²
- Contraindication to total intravenous anesthesia (TIVA)
- Evidence of pulmonary infection before surgery
- Presence of other significant lung diseases such as tuberculosis, bullous lung disease, or bronchiectasis
- Severe chronic obstructive pulmonary disease (COPD) stage III-IV or significant restrictive lung disease
- Age below 18 years or above 80 years, or pregnancy
- American Society of Anesthesiologists (ASA) physical status IV or higher
- Uncontrolled arrhythmia or myocardial infarction within the last 3 months
- Unable to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Health Sciences University Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital
Ankara, Yenimahalle, Turkey (Türkiye), 06200
Actively Recruiting
Research Team
Ö
Ökkeş Hakan Miniksar, Assoc.Prof
CONTACT
S
Seher Altınel, Assoc.Prof
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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