Flow-controlled ventilation - a new and promising method of ventilation presented with a review of the literature.
Szymon Bialka, Piotr Palaczynski, Konstanty Szuldrzynski...
https://pubmed.ncbi.nlm.nih.gov/35142160Actively Recruiting
Age: 18Years - 80Years
All Genders
ID07392086
Comparison of Flow-Controlled Ventilation (FCV) and Volume-Controlled Ventilation (VCV) Effects on Respiratory Mechanics and Gas Exchange During One-Lung Ventilation: A Multicenter Observational Study
Led by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Updated on 2026-02-06
60
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
D
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Lead Sponsor
K
Kocaeli City Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
One-lung ventilation (OLV) is a common technique used during thoracic surgery but can negatively affect lung function and gas exchange. Researchers are studying and comparing two different ventilation methods, flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV), to see how they impact respiratory mechanics and oxygen levels during OLV in adult patients. This multicenter, prospective observational study aims to provide real-world evidence on these ventilation strategies to better understand their benefits and limitations. Patients undergoing thoracic surgery will receive either FCV or VCV as part of their usual care, without any changes made for the study. FCV is a newer method that precisely controls airflow during breathing cycles, while VCV is a commonly used conventional ventilation mode. Data on lung function, airway pressures, oxygenation, and gas exchange will be collected at specific times during both two-lung and one-lung ventilation phases during surgery. Participants will be monitored throughout their surgery with measurements of respiratory mechanics, blood oxygen levels, and other clinical parameters. The study will assess lung compliance, airway pressures, oxygenation capacity, and carbon dioxide elimination during OLV. This information will help improve understanding of lung-protective ventilation during thoracic surgery. The study includes adult patients aged 18 to 80 years and lasts for the duration of the surgical procedure with data collected intraoperatively.
CONDITIONS
Brief Title
Comparison of FCV and VCV in One-Lung Ventilation
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years and older
- Patients undergoing thoracic surgery requiring one-lung ventilation (OLV)
- Requirement for one-lung ventilation for at least 30 minutes
- American Society of Anesthesiologists (ASA) physical status I-III
- Provision of written informed consent
- Patients ventilated with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine clinical practice
You will not qualify if you...
- Requirement for emergency surgery
- History of untreated asthma
- High pulmonary risk defined as predicted postoperative FEV1 < 20 mL/kg in males and < 18 mL/kg in females
- High cardiac risk including advanced cardiomyopathy with left ventricular ejection fraction < 30%
- Body mass index (BMI) > 35 kg/m²
- Contraindication to total intravenous anesthesia (TIVA)
- Evidence of pulmonary infection prior to surgery
- Presence of other significant pulmonary pathologies such as tuberculosis, bullous lung disease, or bronchiectasis
- Severe COPD (GOLD stage III-IV) or significant restrictive lung disease
- Age under 18 years or over 80 years, or pregnancy
- ASA physical status IV or higher
- Uncontrolled arrhythmia or history of myocardial infarction within the past 3 months
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Day of surgery
Participants undergo thoracic surgery requiring one-lung ventilation with ventilation mode determined by routine clinical practice.
1 visit (in-person)
Monitoring
Duration - Intraoperative period during one-lung ventilation
Participants are observed during and after surgery for respiratory mechanics and gas exchange parameters as part of routine clinical care.
Data collected at predefined time points during surgery
Trial Site Locations
Total: 1 location
1
Health Sciences University Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital
Ankara, Yenimahalle, Turkey (Türkiye), 06200
Actively Recruiting
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Research Team
Ö
Ökkeş Hakan Miniksar, Assoc.Prof
S
Seher Altınel, Assoc.Prof
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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