Actively Recruiting
Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.
Led by Lahore General Hospital · Updated on 2026-03-13
60
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective RCT investigates if a single 4 ml intra-articular PRP injection improves knee function after ACL reconstruction using peroneus longus autograft. In Pakistan's resource-limited context, 88 patients (18-50 years) with isolated ACL tears receive either PRP or saline during surgery, then randomized equally. KOOS4 scores compared at 3, 6, and 12 months via ANCOVA (adjusted baseline, α=0.05). Positive results could establish affordable enhancement for recovery and guide practice in similar settings.
CONDITIONS
Official Title
Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 50 years
- Diagnosis of a primary, complete ACL tear requiring reconstruction
- Willingness to undergo arthroscopic ACL reconstruction with peroneus longus autograft
- Active individuals participating in sports or regular physical activity
- Willingness to provide informed consent and follow study protocol, including follow-up visits and rehabilitation
- Ability to understand and complete study questionnaires
You will not qualify if you...
- Previous knee surgery on the affected limb
- Additional ligament injuries requiring reconstruction (e.g., PCL, MCL, LCL Grade III)
- Significant cartilage damage (Outerbridge grade > 2)
- Pre-existing knee osteoarthritis (Kellgren-Lawrence grade > 2)
- Systemic inflammatory diseases (e.g., rheumatoid arthritis)
- Bleeding disorders or use of anticoagulant medications
- Corticosteroid injection into the knee within 6 weeks before surgery
- Pregnancy or breastfeeding
- Inability to follow rehabilitation protocol
- Infection or history of infection in the affected knee
- Previous ACL injury on the opposite knee
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lahore General Hospital
Lahore, Punjab Province, Pakistan, 54000
Actively Recruiting
Research Team
H
Hafiz Sohail Ahmad, Dr
CONTACT
A
Abdul Subhan Zahid, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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