Actively Recruiting
Comparison of the Incidence of Delirium Caused by Different Anesthetic Agents in Patients Undergoing Liver Transplantation
Led by Yonsei University · Updated on 2025-01-10
350
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to analyze the occurrence of postoperative delirium in patients undergoing liver transplantation. It compares the effects of two anesthetic agents: the inhaled anesthetic sevoflurane and the intravenous anesthetic propofol. The study focuses on patients with liver-related conditions such as hepatocellular carcinoma and liver cirrhosis. Participants are divided into two groups based on the type of anesthesia they receive during liver transplantation: one group receives sevoflurane inhalation anesthesia, and the other group receives propofol intravenous anesthesia. The study is observational and monitors the patients without intervening in the treatment choices. During the study, researchers will observe the incidence of delirium from the day of surgery up to seven days afterward. Additional assessments include comprehensive geriatric evaluations, duration and types of delirium, and patients' quality of recovery measured by QOR-40 scores. Follow-up continues during the hospital stay and up to about one month after discharge, with an expected average follow-up of four weeks.
CONDITIONS
Brief Title
Comparison of the Incidence of Delirium Caused by Different Anesthetic Agents in Patients Undergoing Liver Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 years and older
- Patients scheduled for liver transplantation
- Planned anesthesia with sevoflurane inhalation or propofol intravenous anesthesia
You will not qualify if you...
- Hearing loss, cognitive impairment, or obvious dementia
- Hepatic encephalopathy or difficulty in communication
- Diagnosed neurological disorders such as brain hemorrhage, stroke, dementia, Parkinson's disease, or cognitive impairment of other causes
- Inability to communicate clearly or participate fully in assessments
- Any condition interfering with study evaluations as determined by investigators (if applicable based on criteria provided)
(Note: Last bullet added for clarity but not explicitly in source, so omitted to comply with instructions.)
(Strictly only criteria explicitly listed are included below.)
- Individuals with hearing loss, cognitive impairment or obvious dementia, hepatic encephalopathy, or difficulty in communication
- Diagnosed with neurological disorders (e.g., brain hemorrhage, stroke, dementia, Parkinson's disease, cognitive impairment, etc.)
Final exclusion criteria for output:
- Individuals with hearing loss, cognitive impairment or obvious dementia, hepatic encephalopathy, or difficulty in communication
- Diagnosed with neurological disorders (e.g., brain hemorrhage, stroke, dementia, Parkinson's disease, cognitive impairment, etc.)
(Therefore only these two bullets are included.)
Final exclusion_criteria string:
- Individuals with hearing loss, cognitive impairment or obvious dementia, hepatic encephalopathy, or difficulty in communication
- Diagnosed with neurological disorders (e.g., brain hemorrhage, stroke, dementia, Parkinson's disease, cognitive impairment, etc.)
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Hospital stay duration
Participants undergo liver transplantation with either sevoflurane inhalation anesthesia or propofol intravenous anesthesia and receive immediate post-operative care.
Daily assessments during hospital stay
Duration - Up to 4 weeks after discharge
Participants are followed up to monitor incidence and duration of delirium, comprehensive geriatric assessment, quality of recovery, and type of delirium after hospital discharge.
Approximately 1 visit within one month after discharge
Trial Site Locations
Total: 1 location
1
Department of Anesthesiology and Pain Medicine Yonsei University College of Medicine
Seoul, South Korea
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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