Study Comparing Inflammatory Markers and Liver Regeneration in Alcoholic Liver Disease and Other Liver Conditions

What this Trial Is About

Researchers are comparing the levels of pro-inflammatory cytokines in patients with alcoholic hepatitis to those in two other groups patients with alcoholic cirrhosis and patients without chronic liver disease. The study aims to understand the inflammatory profiles and regenerative potential in alcoholic liver disease. This comparison may help clarify differences in immune response and liver regeneration among these groups. The study involves collecting liver biopsies and blood samples from three groups patients with acute alcoholic hepatitis, patients with alcoholic cirrhosis, and patients without chronic liver disease. Each group undergoes tissue and blood collection to analyze inflammatory markers and genetic variants related to liver disease. These samples will be examined for proinflammatory cytokine expression, cell damage markers, and regeneration indicators. Participants will have their liver tissue and blood tested at baseline to assess inflammation and liver cell changes. Researchers will measure expression of specific cytokines, genetic variants, and markers of cell death and regeneration. The study does not involve randomization or masking. It is expected to continue through September 2027, with detailed lab analyses guiding the understanding of liver disease progression and immune responses.

Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease