Actively Recruiting
Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
Led by University Hospital, Brest · Updated on 2025-04-04
250
Participants Needed
12
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if intubated in pre -hospital) by Isoflurane using an ANACONDA ™ type system, compared to a conventional intravenous sedation strategy.
CONDITIONS
Official Title
Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18 and over
- Patient requiring mechanical ventilation for at least 24 hours
- Patient requires continuous and immediate sedation for comfort, safety, and survival measures
- Consent obtained from patient or relative
You will not qualify if you...
- Hospitalized due to cardiac arrest
- State of refractory epilepticus
- Head trauma
- Stroke
- Hearing, visual, or aphasia disorders preventing CAM-ICU assessment
- Sedation started more than 24 hours ago
- Cognitive impairment or dementia
- Contraindication to halogenated gases (malignant hyperthermia history, neuromuscular disease, severe liver insufficiency)
- Severe acute respiratory distress syndrome (PaO2/FiO2 <100 after ventilation optimization)
- PaCO2 > 50 mmHg after ventilation optimization
- Planned limitation of active therapies
- Under guardianship or curatorship
- Minor patient
- Pregnant or breastfeeding woman
- Not affiliated with social security scheme
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
CH Bourges
Bourges, France, 18000
Actively Recruiting
2
CHU de Brest
Brest, France, 29200
Actively Recruiting
3
CH Corbeil Essonnes
Corbeil-Essonnes, France, 91106
Actively Recruiting
4
CH Le Mans
Le Mans, France, 72039
Actively Recruiting
5
GHBS Lorient
Lorient, France, 56322
Actively Recruiting
6
CH Melun
Melun, France, 77000
Actively Recruiting
7
CHU Montpellier
Montpellier, France, 34295
Suspended
8
CH Morlaix
Morlaix, France, 29672
Actively Recruiting
9
CHU Poitiers
Poitiers, France, 86021
Actively Recruiting
10
CHU Rennes
Rennes, France, 35033
Actively Recruiting
11
CHU Tours - Réanimation Chirurgicale
Tours, France, 37044
Not Yet Recruiting
12
CHU Tours
Tours, France, 37044
Actively Recruiting
Research Team
P
Pierre Bailly, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here