Comparison of Intravenous Lidocaine and Ketamine Effects on Inflammation in Adults Undergoing Open Colorectal Cancer Surgery

What this Trial Is About

Researchers are evaluating the effects of intravenous Lidocaine versus intravenous Ketamine in patients undergoing open colorectal surgery for cancer. This randomized controlled trial aims to compare how these two drugs influence inflammation by measuring Interleukin-6 IL-6 levels before anesthesia and 24 hours after surgery. The study also assesses pain, nausea, bowel function, hospital stay length, and postoperative complications to better understand treatment impacts. Participants are randomly assigned to one of two groups. The Lidocaine group receives a loading dose of 1.5 mgkg followed by a continuous infusion of 1.5 mgkg per hour for 24 hours. The Ketamine group receives a loading dose of 0.15 mgkg followed by a continuous infusion of 0.15 mgkg per hour over the same period. Both treatments are administered intravenously during and after surgery. During the study, patients will have blood samples taken to measure IL-6 levels before anesthesia and 24 hours after surgery. Pain will be evaluated using a numerical scale at 2, 12, and 24 hours postoperatively. Nausea, vomiting, bowel function, length of hospital stay, and complications will be monitored for up to 15 days after surgery. The entire participation includes treatment and follow-up assessments to observe recovery and outcomes.

Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery