Actively Recruiting
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Led by University Tunis El Manar · Updated on 2025-11-18
50
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
CONDITIONS
Official Title
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 or older.
- American Society of Anesthesiologists (ASA) physical status of I-III.
- Scheduled for elective open colorectal surgery.
You will not qualify if you...
- Contraindications to lidocaine or ketamine.
- Corticosteroid therapy within the last 6 months.
- History of immunosuppressive therapy.
- Surgery within the last 3 months.
- Personal history of inflammatory bowel disease.
- Personal history of cardiac arrhythmias or conduction disorders.
- Alcohol or drug abuse.
- Chronic use of opioids or benzodiazepines.
- Severe intraoperative complications.
- Surgery duration longer than 5 hours.
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Trial Site Locations
Total: 1 location
1
Tunisia
Nabeul, Tunisia, 8000
Actively Recruiting
Research Team
B
BEN ALI MECHAAL, Professor
CONTACT
K
KTATA HIBA, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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